UoM Cell Metabolism Lecture 11-15 Lipids and Plant Lipids (Year 2, Sem 2, 2017)

uom-cell-metabolism-lecture-11-15-lipids-and-plant-lipids-year-2-sem-2-2017

出口

题 1 of 1

剩下的时间

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240

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ACC2 is needed for regulation of FA b-oxidation in the mitochondrial matrix, so what happens to knockout ACC2 mice?

选择正确的答案

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264812

240

none

Lipids can be used as metabolic fuel as they are highly reduced and hydrophobic, allowing oxidation to generate energy! Inconversion to lipids , we know that acetyl coa is irreversibly turned into malonyl CoA using ATP, but by which molecule? (malonyl-CoA used

选择正确的答案

(0/0)

265068

240

none

Ketone bodies are an alternative route that occurs beta-oxidation of FA is high or glucose availability is low. It is synthesised by the liver, taken up as water soluble FA derived fuel. Why isn't it used in the liver?

选择正确的答案

(0/0)

264813

240

none

Malonyl CoA is made from acetyl CoA in the formation of lipids via ACC (acetyl CoA carboxylase), but what does Fatty acid synthase (FAS) do to Malonyl CoA with another ATP and 2NADPH?

选择正确的答案

(0/0)

265069

240

none

Ketogenesis is where ketone bodies are used as lipid derived fuel that spares glucose use and spares muscle protein use. The brain gets its energy from ketone bodies only when glucose is extremely sparse, but which organ receives a lot of its energy from ketone bodies?

选择正确的答案

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264814

240

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Order the steps involved in fatty acid chain formation by malonyl CoA addition by Fatty acid synthase (uses 1 ATP and 2 NADPH per cycle).

匹配文本（单击并拖动）

(0/0)

匹配文本
1
2
3

单击并拖动
Malonyl unit is transferred from CoA to FAS
Repeated with a second malonyl unit for FA chain
Cycle of reactions occurs... adding 2 carbons onto a growing FA chain

265070

240

none

Diabetic ketoacidosis is when the ketone bodies in the blood becomes too high, acidifying the blood. The increased lipolysis, circulating Fa's, increased beta-oxidation and gluconeogenesis lowers the ph... why is this bad?

选择正确的答案

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264815

240

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Intermediates do not leave the FAS and FA synthesis occurs in the cytosol (acetyl coa moves out of mitochondria to use), how DOESN'T this help the reactions dynamics?

选择正确的答案

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265071

180

none

The plants have a very different method of FA and TAG synthesis/regulation, with many health benefits through molecules like omega-3 FA's. Why are plant foods usually a lot better for you?

选择正确的答案

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264816

240

none

In fatty acid synthesis acetyl CoA is turned into malonyl CoA by ACC and ATP, then FAS forms fatty acids from it using 1 ATP and 2 NADPH per cycle. Match the origin of the important molecules with its name.

匹配文本（单击并拖动）

(0/0)

匹配文本
Acetyl-CoA
NADPH
ATP

单击并拖动
From fatty acid oxidation or the aerobic/anaerobic cycle
From pentose phosphate pathway and from transport of Acetyl-CoA into the cytosol
From glycolysis (pyruvate) and amino acids, mainly from mitochondria

265072

240

none

There are 3 main types of plant fatty acids, saturated ones, monounsaturated ones and polyunsaturated ones. Lipids are the main storage molecule in plant rather than starch/fructan, which is why it's usually in seeds. Why are TAG's not made even though they hold more energy than starch?

选择正确的答案

(0/0)

264817

240

none

Fatty acid synthesis is maximal at high carb and ATP conditions, converting excess into fat. Match the control mechanism type with its relevant mechanisms in fatty acid synthesis.

匹配文本（单击并拖动）

(0/0)

匹配文本
Fine control
Course control

单击并拖动
Covalent modification and allostery of ACC
Transcriptional, translational and degradational FAS and ACC

264818

240

none

ACC is a very important enzyme, with control not only fine (covalent and allosteric modding) and coarse (translational/scription, degradation) but multi levelled. Match the level of control with the relevant mechanisms.

匹配文本（单击并拖动）

(0/0)

匹配文本
Global Control
Local control
Long term control

单击并拖动
ACC synthesis and degradation changed via diet
Allosteric effects like citrate, FA's or AMP, regularing enzymes activity according to each individual cell
Insulin (syn), glucagon (deg), adrenaline control (deg) of ACC phosphorylation, according to whole organisms status

265074

240

none

The plastids of oil producing cells can switch from starch producing (in embryo development) to lipid production. What complex plant plastid molecules regulates this synthesis?

选择正确的答案

(0/0)

264819

300

none

We know phosphorylation is an important fine covalent modification of ACC (phos = inactive). There is an important enzyme in using ATP and phosphorylating ACC with ATP, positively increased by glucagon and adrenaline raising cAMP. What is this enzyme called?

UoM Cell Metabolism Lecture 11-15 Lipids and Plant Lipids (Year 2, Sem 2, 2017)

题 1 of 1

剩下的时间

ACC2 is needed for regulation of FA b-oxidation in the mitochondrial matrix, so what happens to knockout ACC2 mice?

选择正确的答案

(0/0)

Lipids can be used as metabolic fuel as they are highly reduced and hydrophobic, allowing oxidation to generate energy! Inconversion to lipids , we know that acetyl coa is irreversibly turned into malonyl CoA using ATP, but by which molecule? (malonyl-CoA used

选择正确的答案

(0/0)

Ketone bodies are an alternative route that occurs beta-oxidation of FA is high or glucose availability is low. It is synthesised by the liver, taken up as water soluble FA derived fuel. Why isn't it used in the liver?

选择正确的答案

(0/0)

Malonyl CoA is made from acetyl CoA in the formation of lipids via ACC (acetyl CoA carboxylase), but what does Fatty acid synthase (FAS) do to Malonyl CoA with another ATP and 2NADPH?

选择正确的答案

(0/0)

Ketogenesis is where ketone bodies are used as lipid derived fuel that spares glucose use and spares muscle protein use. The brain gets its energy from ketone bodies only when glucose is extremely sparse, but which organ receives a lot of its energy from ketone bodies?

选择正确的答案

(0/0)

Order the steps involved in fatty acid chain formation by malonyl CoA addition by Fatty acid synthase (uses 1 ATP and 2 NADPH per cycle).

匹配文本（单击并拖动）

(0/0)

1

2

3

Malonyl unit is transferred from CoA to FAS

Repeated with a second malonyl unit for FA chain

Cycle of reactions occurs... adding 2 carbons onto a growing FA chain

Diabetic ketoacidosis is when the ketone bodies in the blood becomes too high, acidifying the blood. The increased lipolysis, circulating Fa's, increased beta-oxidation and gluconeogenesis lowers the ph... why is this bad?

选择正确的答案

(0/0)

Intermediates do not leave the FAS and FA synthesis occurs in the cytosol (acetyl coa moves out of mitochondria to use), how DOESN'T this help the reactions dynamics?

选择正确的答案

(0/0)

The plants have a very different method of FA and TAG synthesis/regulation, with many health benefits through molecules like omega-3 FA's. Why are plant foods usually a lot better for you?

选择正确的答案

(0/0)

In fatty acid synthesis acetyl CoA is turned into malonyl CoA by ACC and ATP, then FAS forms fatty acids from it using 1 ATP and 2 NADPH per cycle. Match the origin of the important molecules with its name.

匹配文本（单击并拖动）

(0/0)

Acetyl-CoA

NADPH

ATP

From fatty acid oxidation or the aerobic/anaerobic cycle

From pentose phosphate pathway and from transport of Acetyl-CoA into the cytosol

From glycolysis (pyruvate) and amino acids, mainly from mitochondria

There are 3 main types of plant fatty acids, saturated ones, monounsaturated ones and polyunsaturated ones. Lipids are the main storage molecule in plant rather than starch/fructan, which is why it's usually in seeds. Why are TAG's not made even though they hold more energy than starch?

选择正确的答案

(0/0)

Fatty acid synthesis is maximal at high carb and ATP conditions, converting excess into fat. Match the control mechanism type with its relevant mechanisms in fatty acid synthesis.

匹配文本（单击并拖动）

(0/0)

Fine control

Course control

Covalent modification and allostery of ACC

Transcriptional, translational and degradational FAS and ACC

ACC is a very important enzyme, with control not only fine (covalent and allosteric modding) and coarse (translational/scription, degradation) but multi levelled. Match the level of control with the relevant mechanisms.

匹配文本（单击并拖动）

(0/0)

Global Control

Local control

Long term control

ACC synthesis and degradation changed via diet

Allosteric effects like citrate, FA's or AMP, regularing enzymes activity according to each individual cell

Insulin (syn), glucagon (deg), adrenaline control (deg) of ACC phosphorylation, according to whole organisms status

The plastids of oil producing cells can switch from starch producing (in embryo development) to lipid production. What complex plant plastid molecules regulates this synthesis?

选择正确的答案

(0/0)

We know phosphorylation is an important fine covalent modification of ACC (phos = inactive). There is an important enzyme in using ATP and phosphorylating ACC with ATP, positively increased by glucagon and adrenaline raising cAMP. What is this enzyme called?

选择正确的答案

(0/0)

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