What is this?
Hyaline membrane disease
Name features of pulmonary fibrosis
Thickened alveolar walls (deposition of collagen), variable chronic inflam infiltrate (lymphocytes predominantly), Mainly type 2 pneumocytes.
Usual interstitial pneumonia
How do the nodules of collagenous tissue form in silicosis?
Macrophages phagocytose inhaled silica particles, then accumulate in clumps. These provoke a focal fibrotic reaction with collagenous nodule formation. The centre of the nodules become acellular and hyaline is surrounded by a cellular fibrous tissue containing macrophages laden with black carbon.
What does this show?
Silicosis - collagenous tissue forming a nodule
What is this? How does the process continue?
Silicosis - fibrotic nodules can coalesce causing widespread pulmonary fibrosis.
What is the most common pneumoconiosis?
Silicosis (others include asbestosis and berylliosis)
What do asbestos fibres become when inhaled into the lung parenchyma?
Segmented Asbestos bodies (asbestos fibres coated in proteinaceous material)
What cells are involved in the response to asbestos fibres?
Macrophages and giant cells
Most common tumour caused by asbestos exposure?
Bronchogenic carcinoma (mesothelioma is more rare although specific to asbestos)
Most common primary malignancy of lung?
Sq Cell Carcinoma
Site of Sq cell carcinoma of lung?
Main bronchi / larger branches i.e. where squamous metaplasia has happened due to smoking
What are some features of sq cell carcinoma of lung?
Typical Sq Cell carcinoma features with varying degrees of differentiation. i.e. well diff keratinising type or poorly diff with IC bridges only visible at high power.
Small cell carcinoma of the lung - main site?
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