`The branch of science that seeks to
understand the effects of drugs on
the human body with the intention of
preventing, curing or alleviating
Who is the Patron Saint of Pharamcy?
Who invented the term pharmacology?
List some of the trailblazers in Pharmacology and outline their significance?
1. Samuel Dale: British pharmacist and physician. Had an interest in plant; describing their medicinal use in Pharmacologia (1693). Invented the term pharmacology from greek words: 'Pharmakon' (drug) and Logia (word).
2. Johann Christian Reil: 1797, worte key paper 'An article on the principles for a future pharmacology'. Proposed 8 rules for pharmacology.
List 3 famous medicinal plants and their associated 'drug' and effect.
1. Willow Tree. Salicylates -> Aspirin. Provides analgesic. antipyretic and anti-inflammatory affect.
2. Belladonna. Atropine. Used as a pupil dilator.
3. Sweet Annie. Artesunate. Contains active ingredient atemisinin which is an antimalarial.
Who is the Father of Modern Chemistry?
Describe some of the problems slowing the emergence of pharamacology?
1. Not enough effective drugs. Many plant based with efficacy, stability, purity issues etc.
2. Poor understnading of scientific principles
3. Poor appreciation for need of well-controlled trials and investigations.
When did modern pharmacology emerge?
Modern pharmacology emerged in the late 19th century in Germany. It paralleled advances in chem, physiology, natomy, path etc.
What are the three ways in which drugs are named?
1. Chemical name. 2. Generic name. 3. Brand name
Example. 1.n-(4-hydroxyphenyl)ethanamide. 2. Paracetemol. 3. Panandol etc.
Name an antidepressant (SSRI) and give its generic and one brand name?
Simply: 'what the drug does to the body'.
Branch of pharmacology concerned with the effects of drugs and the mechanism of their action.
what is pharmacokinetics?
Simply: 'what the body does to the drug'
the branch of pharmacology concerned with the movement of drugs within the body. Specifically, their absorption, distribution, metabolism and excretion.
Explain the pharmacodynamics of fluoxetine....
Molecular: drug binds to serotonin transporter.
Cellular: Neuronal reuptake of serotonin inhibited.
Tissue Level: Lowers activity of serotonergic neuronal pathways in CNS.
Whole body: imporved mood and alleviation of depression symptoms.
WHAT IS ADME?
Absorption is the transfer of drugs from the site of administration to the systemic circulation.
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