Nucleic Acids

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Splicing

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Segments of the gene that contain sequences that form part of the final RNA are called

The remaining sequences are called

These sequences are transcribed but edited out of the final mature mRNA.

The primary transcript needs to be modified, the introns need to be

Introns start with the sequence GU and end with

The intron has the general sequence: GU.....Pyr15NCAG with pyr15 meaning any 15 pyrimidines and N meaning any nucleotide

The AGGU sequence that ends the exon and starts the intron is called

ad the Pyr15NCAG sequence at the end of the intron is called the splice acceptor sequence.

RNA processing uses small nuclear ribonucleoproteins (snRNPs

The first one to bind is U1 which binds to the splice donor sequence which is

The next ones to bind are

U5 binds to the splice acceptor sequence

The binding of the snRNPs completes the spliceosome which results in the cleavage of the

AG on the exon separates from the GU via the hydrolysis of the phosphodiester bond between the two

The GU can move freely, it loops freely back to an

residue on the intron. The G forms a phosphodiester bond with this residue between the 5' phosphate group on the G and the 2 OH' group on the G

This causes the

to be cleaved, the end of the intron is removed from the next exon and the intron is removed as a

The cell detects this and removes it



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