Grafts in Huntington's Disease

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What DID Cichetti et al.'s (2009) patients show?

Graft survival is attenuated long-term in the caudate-putamen, but they undergo disease-like neuronal degeneration with a preferential loss of projection neurons in comparison to interneurons. Glutamatergic cortical neurons projected to transplanted striatal neurons, microglial inflammatory changes in the grafts specifically targeted the neuronal components of the grafts





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