Platelet inhibitor, anti-inflammatory
Binds and adsorbs ingested toxins from the gastrointestinal tract
Binds with hemoglobin to help biodegrade cyanide
Reduces production of thromboxane which mediates platelet aggregation.
Not precisely known, but evidence is that it acts to depress hyper stimulated labyrinthine functions or associated neural pathways. It is also thought to inhibit cholinergic stimulation in the vestibular and associated neural pathways.
Pyrexic child, severe sepsis or septic shock
Acute cyanide poisoning with impaired LOC
Chest pain, cardiac in origin
Relief of nausea and vomiting, can be associated with motion sickness and nausea vomiting associated with Meniere’s Disease, or medication induced N/V particularly Narcotics.
Hypersensitivity, acetaminophen-induced liver disease
Hypersensitivity to ASA or other NSAIDs, active peptic ulcers
Hypersensitivity to dimenhydrinate or tartrazine.
Patients with cardiac history, pregnancy
Do not administer to patient with decreased LOC. If ipecac has been administered, wait 10 minutes.
Potentially fatal hepatotoxicity can result from overdose Patients with liver disease, are malnourished, are chronic alcoholics or are taking medications that induce hepatic enzymes are at greater risk for acetaminophen hepatotoxicity
Tachycardia, nausea/vomiting, hypertension
Tachycardia, palpitations, headache, anxiety, arrhythmias, nausea/ vomiting
Heartburn, nausea/ vomiting, wheezing, prolonged bleeding
nausea/ vomiting, cramping may be seen in overdose in children and nothing noted in adults till liver function deterioration
160 – 325 mg
12 years and older: 1 mg with repeat in 15 min as needed Under 12 years: 0.1 mg/kg to a max of 1 mg with repeat in 15 min as needed
Adult: 25 g, may be repeated as necessary Pediatric: 2 – 4 mL/kg of D25W concentration
Adult: 325-650 mg every 4-6 hours, not to exceed 4000 mg/24 hours, Pediatric: 10-15 mg/kg every 4-6 hours, not to exceed 5 doses in 24 hours
Onset: Immediate Peak effects: Varies Duration: Varies based on gastrointestinal function, will act until excreted
Onset: Immediate (IV), 20-30 minutes (IM) Peak effects: Varies Duration: 3-6 hours
Onset: Within 20 min Peak effects: Varies Duration: 2 – 3 hours
Onset: 1 min Peak effects: 30 min Duration: 1 - 2 hours
Oral – Immediate release tablet (325 mg, 500 mg), caplet (325 mg, 500 mg), extended release caplet (650 mg), gel cap (500 mg), chewable tablet (80 mg, 160 mg), rapidly- dissolving tablet (80 mg , 160 mg), suspension (80 mg/mL, 32 mg/mL) Rectal – Suppository (120 mg, 160 mg, 325 mg, 650 mg)
1 mg/mL (requires reconstitution)
81 mg and 325 mg tablets
Retraining and certification is required by a physician every 2 years
Administer regardless whether patient has taken their daily ASA dose
Always ensure that a blood glucose reading is obtained before administration
Only services that respond to industries where cyanide exposure can occur will stock drug
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