Platelet inhibitor, anti-inflammatory
Carbohydrate, Antihypoglycemic agent
Antipyretic action by acting on heat regulating centers in the hypothalamus causing increased heat loss through vasodilation and sweating Analgesic action by inhibiting prostaglandin synthesis in the central nervous system
Binds with hemoglobin to help biodegrade cyanide
Reduces production of thromboxane which mediates platelet aggregation.
Not precisely known, but evidence is that it acts to depress hyper stimulated labyrinthine functions or associated neural pathways. It is also thought to inhibit cholinergic stimulation in the vestibular and associated neural pathways.
Relief of nausea and vomiting, can be associated with motion sickness and nausea vomiting associated with Meniere’s Disease, or medication induced N/V particularly Narcotics.
Oral poisoning or overdose
Pyrexic child, severe sepsis or septic shock
Acute cyanide poisoning with impaired LOC
Hypersensitivity, acetaminophen-induced liver disease
Hypersensitivity to ASA or other NSAIDs, active peptic ulcers
Patients with cardiac history, pregnancy
Potentially fatal hepatotoxicity can result from overdose Patients with liver disease, are malnourished, are chronic alcoholics or are taking medications that induce hepatic enzymes are at greater risk for acetaminophen hepatotoxicity All acetaminophen containing products taken by patient need to be accounted for during 24 hour period including cough and cold remedies, analgesic or arthritis formulations, and antipyretics
Do not administer to patient with decreased LOC. If ipecac has been administered, wait 10 minutes.
Intracranial pressure – may worsen cerebral edema
Tissue necrosis, local venous irritation
Tachycardia, palpitations, headache, anxiety, arrhythmias, nausea/ vomiting
nausea/ vomiting, cramping may be seen in overdose in children and nothing noted in adults till liver function deterioration
IM, SQ, Nebulized
160 – 325 mg
12 years and older: 1 mg with repeat in 15 min as needed
Adult: 325-650 mg every 4-6 hours, not to exceed 4000 mg/24 hours, Pediatric: 10-15 mg/kg every 4-6 hours, not to exceed 5 doses in 24 hours
0.2 – 0.3 mL inhaled for 15 – 30 sec with breaks for 15 – 30 sec. New ampoule every 3 min till arrival at emergency department
Onset: Less than 1 min Peak effects: Varies Duration: Varies
Onset: Within 20 min Peak effects: Varies Duration: 2 – 3 hours
Onset: Immediate Peak effects: approximately 48 min Duration: 4-6 hours
Onset: Immediate Peak effects: Varies Duration: Varies based on gastrointestinal function, will act until excreted
Oral – tablet (100 mg, 200 mg, 400mg, 600mg, 800mg), chewable tablets (50 mg, 100 mg), capsules (200 mg), suspension (100 mg/2.5mL, 100 mg/5mL), oral drops (40 mg/mL)
Oral – Immediate release tablet (325 mg, 500 mg), caplet (325 mg, 500 mg), extended release caplet (650 mg), gel cap (500 mg), chewable tablet (80 mg, 160 mg), rapidly- dissolving tablet (80 mg , 160 mg), suspension (80 mg/mL, 32 mg/mL) Rectal – Suppository (120 mg, 160 mg, 325 mg, 650 mg)
25 g in 50 mL prefilled syringe
0.2 or 0.3 mL glass ampoule
选择要在Apple App Store上查看的Topgrade应用程序。