Transglutaminases allowing for the cross-link of random collagen fibres in the extra-cellular matrix in the remodelling phase. This increases tensile strength.
After the this collagen fibres longitudinally line up along the affected area.
A fancy term for wound heeling
Proteins that cross link collagen
Growth Factors that stimulate Fibroplasia
The final form of M1 Macrophages
The process of establishing new fibroblast rich tissue
The process of producing collagen
The Process of Collagen Degradation
The process of re-establishing blood supply to the wounded area via establishing new blood vessels from existing blood vessels
Gamma Delta T-Cell
Natural Killer T-Cell
Cytotoxic Killer T-Cel (C8 ve)
Apligraph, created by Organogenesis
Enzyme Skin Sigma
The correct answer is Inflmationary Response, Proliferation and Remodelling.
Haemostasis, Vasoconstriction, Vasoldilation, Platelet Aggregation and ReModelling
Inflamationary Phase (Both Haemostasis (VASOCONSTRICTION) and Inflamationary Response, then Proliferation, then Remodelling
PDGF = Platelet Derived Growth Factor, and is released upon degranulation of Basement Membrane Proteins (Fibrin)
Platelet Derived Growth Factor
Insulin Growth Factor
Von Willibrand Growth Factor
Transforming Growth Factor (Beta)
Transforming Growth Factor (TGF)
Von Willibrand Growth Factor (VWGF)
IGF (Insulin Growth Factor)
PDGF (Platelet Derieved Growth Factor)
Neutrophils, Neutrophils are the first cellular response to the wound, they kill bacteria (eat) and debrade other unwanted substances.
Debride tissue - proteases degrade damaged Extracellular Matrix (ECM)
Secrete Cytokines to Cause Inflamation
Neutrophils 36 to 76 hours
Neutrophils (lasts from 6 to 48 hours)
Macrophages (M1) 6 to 48 hours
Fibroblasts (for whole process)
Lymphocytes (7 Days)
when platelets aggregate and activate, they degranulate and release growth factors (PDGF, IGF, TGF, VWF) and serotonin. Forming platelet plug and changing to vasdilation
Supranormal rates of collagen synthesis and degradation. No change in collagen content
Tensile strength gradually increases due to crosslinking of random collagen fibrils due to the action of transglutaminases
Fibrin forms a extracellular matrix that traps platelets (forming platelet plug). Later fibrin allows for a substrate for fibroblast migration
Restoration of cellular and extracellular function in organs and tissues
Scar formation and hopefully regaining strength and function of original tissue.
Initiation of Angiogenesis
Fibroblasts Degrade, this causes a decrease in collagen levels. Eventually Collagen levels decrease, and collagen becomes normal again.
Collagen Homeostasis is restored when fibroblasts begin to diminish due to increased level of collagen, specifically when rate of type III collagen decreases and the normal ratio of 4 to 1 of Type 1 Collagen to Type 3 Collagen is restored. Collagen Homeostasis occurs when rate of collagen synthesis = rate of collagen degradation
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