It is synonymous with Sry in humans.
It was genetically mapped by the study of patients with Klinefelter and Turner syndromes.
It is synonymous with the H-Y antigen.
The expressed SRY protein has a characteristic highmobility group (HMG), DNA-binding domain.
It is a zinc finger gene on the Y chromosome known as ZFY.
It acts systemically to produce müllerian regression.
It functions normally in patients with hernia uteri inguinale.
It is secreted at 7 to 8 weeks of gestation, representing the initial endocrine function of the fetal testis.
It is secreted by the fetal testis at 10 weeks of gestation, after testosterone production has begun.
It is secreted by the fetal Leydig cells.
Loss of WT1 function has not been associated with genitourinary anomalies.
Mutations in WT1 are associated with adrenocortical carcinoma.
Mutations in WT1 can result in either Denys-Drash or Frasier syndrome.
Duplication of WT1 has been associated with dosagesensitive sex reversal.
The gene was originally isolated in cloning experiments and localized to the X chromosome.
It acts locally to virilize the internal wolffian duct structures.
It enters target tissue by active diffusion.
It acts locally to virilize the urogenital sinus and genital tubercle.
It is produced primarily by the adrenal gland.
It results in regression of the müllerian ducts.
It produces virilization of the urogenital sinus.
It produces virilization of wolffian duct structures.
It is secreted in large quantities by the fetal testis.
It acts locally to produce regression of müllerian structures.
It is converted by 5α-reductase to testosterone in target tissues.
They are characteristically fertile.
They have at least one X and two Y chromosomes.
They are at increased risk for development of adenocarcinoma of the breast.
They undergo replacement of Leydig cells with hyaline.
They bear little resemblance to XX males.
can descend to the scrotum.
is located in the round ligament.
has a reduced number of oocytes.
in the presence of a Y chromosome results in risk for development of gonadoblastoma.
in the presence of a Y chromosome results in increased risk for development of seminoma.
They have gonadal histology different from that of patients with Turner syndrome.
They are at lesser risk for gonadal tumors than are patients with Turner syndrome.
They derive similar benefit from synthetic growth hormone as do patients with Turner syndrome.
They frequently have chromosomal anomalies.
They lack the somatic defects associated with Turner syndrome.
Progressive renal failure
Nephropathy with early-onset proteinuria
They have normal testosterone and elevated estradiol levels.
They have castrate testosterone and normal gonadotropin levels.
They have castrate testosterone and elevated gonadotropin levels.
They have normal follicle-stimulating hormone but decreased luteinizing hormone levels.
They have normal testosterone but decreased DHT levels.
It has testicular and ovarian elements randomly distributed.
It cannot descend from the retroperitoneum.
It is found in the minority of patients.
It can be unilateral or bilateral.
It is impossible to cleave surgically.
the familial pattern of inheritance of the disorder.
that malignant degeneration of gonads does not occur.
the impossibility of precisely dividing an ovotestis surgically.
the unresponsiveness of the external genitalia to testosterone.
the potential for fertility.
It is transmitted in an autosomal dominant pattern.
It occurs as a result of gene inactivation in the majority of cases.
It occurs with simple virilization in 75% of cases and salt wasting in 25% of cases.
It accounts for 99% of CAH cases.
It occurs with a predictable phenotype.
is of no risk to the fetus.
is initiated after a diagnosis of CAH is confirmed.
acts by suppressing maternal corticotropin.
is demonstrated to be effective.
is appropriate therapy in seven of eight at-risk fetuses.
They appear clinically with a predictable phenotype.
They are associated with persistent müllerian structures.
They are transmitted in an autosomal dominant pattern.
They may involve impaired glucocorticoid and mineralocorticoid synthesis.
They may be associated with fertility.
選擇要在Apple App Store上查看的Topgrade應用程序。