Case 2 - Kidneys

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Describe how CKD can cause osteodystrophy

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In CKD there is a decrease in renal mass so you get a decrease in

This results in a decrease in the renal excretion of

The increase in plasma Pi stimulates

levels to increase - this is responsible for stimulating kidneys to excrete more Pi. In CKD, the production of 1,25 VitD3

VitD3 is responsible for regulating

uptake, so less is reabsorbed in CKD. Low plasma Ca also stimulates the release of

which causes Ca to be released from

leading to osteoporosis. Ca release from bones increases Ca, but also Pi in the form of

This precipitates, leading to

of soft tissues and arteries.



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