Sympathetic ganglion neurons have been considered as a source of cell replacement in PD as they express what in culture and a rat model?
Sympathetic ganglion neurons have been considered as a source of cell replacement in PD as they express AADC and VMAT2 (proteins involved in the production and transport of dopamine) in culture, as well as following transplantation in a rat model
The action of sympathetic ganglion neuron transplantation is though be mediated by what ability?
Action thought to be mediated by ability to convert and store dopamine found in extracellular space
Clinical studies harvest SG tissues from where?
Clinical studies harvest SG tissues from cervical or thoracic sympathetic trunks and transplant into striatum of PD patients
What proportion of patients in a clinical study had reduced 'off' time and inc. 'on' time? What change was there in the UPDRS?
Approx. half had reduced ‘off’ time and increased ‘on’ time but no sig. change in UPDRS scores
What problem is there with sympathetic ganglion neuron grafts?
Invasive techniques and associated morbidity of procedure involved in obtaining donor tissue
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