Platelet inhibitor, anti-inflammatory
Binds and adsorbs ingested toxins from the gastrointestinal tract
Binds with hemoglobin to help biodegrade cyanide
Reduces production of thromboxane which mediates platelet aggregation.
Not precisely known, but evidence is that it acts to depress hyper stimulated labyrinthine functions or associated neural pathways. It is also thought to inhibit cholinergic stimulation in the vestibular and associated neural pathways.
Chest pain, cardiac in origin
Pyrexic child, severe sepsis or septic shock
Acute cyanide poisoning with impaired LOC
Relief of nausea and vomiting, can be associated with motion sickness and nausea vomiting associated with Meniere’s Disease, or medication induced N/V particularly Narcotics.
Hypersensitivity to ASA or other NSAIDs, active peptic ulcers
Hypersensitivity to dimenhydrinate or tartrazine.
Hypersensitivity, acetaminophen-induced liver disease
Potentially fatal hepatotoxicity can result from overdose Patients with liver disease, are malnourished, are chronic alcoholics or are taking medications that induce hepatic enzymes are at greater risk for acetaminophen hepatotoxicity
Do not administer to patient with decreased LOC. If ipecac has been administered, wait 10 minutes.
Patients with cardiac history, pregnancy
Tachycardia, nausea/vomiting, hypertension
nausea/ vomiting, cramping may be seen in overdose in children and nothing noted in adults till liver function deterioration
Tachycardia, palpitations, headache, anxiety, arrhythmias, nausea/ vomiting
Heartburn, nausea/ vomiting, wheezing, prolonged bleeding
Adult: 25 g, may be repeated as necessary Pediatric: 2 – 4 mL/kg of D25W concentration
12 years and older: 1 mg with repeat in 15 min as needed Under 12 years: 0.1 mg/kg to a max of 1 mg with repeat in 15 min as needed
Adult: 325-650 mg every 4-6 hours, not to exceed 4000 mg/24 hours, Pediatric: 10-15 mg/kg every 4-6 hours, not to exceed 5 doses in 24 hours
160 – 325 mg
Onset: Within 20 min Peak effects: Varies Duration: 2 – 3 hours
Onset: 1 min Peak effects: 30 min Duration: 1 - 2 hours
Onset: Immediate Peak effects: Varies Duration: Varies based on gastrointestinal function, will act until excreted
Onset: Immediate (IV), 20-30 minutes (IM) Peak effects: Varies Duration: 3-6 hours
81 mg and 325 mg tablets
1 mg/mL (requires reconstitution)
Oral – Immediate release tablet (325 mg, 500 mg), caplet (325 mg, 500 mg), extended release caplet (650 mg), gel cap (500 mg), chewable tablet (80 mg, 160 mg), rapidly- dissolving tablet (80 mg , 160 mg), suspension (80 mg/mL, 32 mg/mL) Rectal – Suppository (120 mg, 160 mg, 325 mg, 650 mg)
Only services that respond to industries where cyanide exposure can occur will stock drug
Always ensure that a blood glucose reading is obtained before administration
Administer regardless whether patient has taken their daily ASA dose
Retraining and certification is required by a physician every 2 years
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