Biology of Cancer

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  Thời Gian Còn Lại


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Sustained proliferative signalling (too many go signals)

Normal cell: carefully control production and release of growth-promoting signals. Signals instruct entry and progression through cell cycle – ensuring overall homeostasis Cancer cell enables signals: Increasing GF production Stimulating normal cells in the microenvironment to provide cancer cells with GF Increasing the number of receptors on the cell surface Structurally altering receptors to facilitate cancer cell signaling Activating proteins in the downstream signaling pathway Disruption of negative feedback loops (safety mechanism to dampen a signaling pathway whenever a mitogenic signal is hyperactivated) e.g. Ras oncoprotein 1 - Oncogenic activity of Ras is not the result of overactive Ras signaling but rather the disruption of normal negative feedback mechanisms operated by the oncogenic GTPase e.g. Loss-of-function mutations in phosphatase and tensin homolog (PTEN), which amplify phosphatidylinositol 3-kinase (PI3K) signaling





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