IMMUNOLOGY

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0 [{"id":197740,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-04 12:13:41","updated_at":"2017-05-04 12:13:41","questionName":"How many HLA\/MHC molecules does each cell express?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"-\tEach person inherits 1x HLA-A, B, C from each parent and so has 2x HLA-A, B, C -\tEach person inherits 1x HLA- DR, DQ, DP from each parent and so has 2x HLA- DR, DQ, DP -\tEach cell expresses x 6 Class I and x 6 Class II MHC (HLA) molecules","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197783,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-04 14:49:36","updated_at":"2017-05-04 14:49:36","questionName":"Which of the following has the LOWEST RISK of REJECTION?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"The cornea is an \u2018immune privileged\u2019 site \u2013 no circulating lymphocytes as they are excluded by the blood brain barrier -\tAnd lymphocytes are needed for rejection \u2013 so LOW risk or rejection ","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197741,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-04 12:19:59","updated_at":"2017-05-04 12:19:59","questionName":"Explain TRANSPLANT REJECTION? (alloreactive response)","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197756,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-04 14:02:15","updated_at":"2017-05-04 14:12:05","questionName":"My brother has given me one of his kidneys - and now I need a liver transplant and he's keen to give me part of his - what could go wrong.......?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"Hyper Acute Rejection -\tT cell mediated response (predominantly CD8, but also CD4) -\tNormal immune response \u2013 starting with the innate response then hours\/days later the adaptive response is activated -\tIf you then use ANOTHER graft from the SAME donor \u2013","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197743,"quiz_id":"11772","answer_id":null,"answerType_id":"2","created_at":"2017-05-04 12:32:51","updated_at":"2017-05-04 12:32:51","questionName":"Match the types of tissue rejection","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197781,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-04 14:47:53","updated_at":"2017-05-04 14:47:53","questionName":"How would you TREAT rejection?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"To stop the inflammation and attack - you need to remove the T cells (with antithymocyte globulin) and to deal with the antibody rejection (give retuximab - to remove B cells)","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197758,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-04 14:09:52","updated_at":"2017-05-04 14:10:34","questionName":"Why is ACUTE REJECTION RARELY seen in humans?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"-\tAcute rejection rarely seen in humans (immunosuppression) o\tThe recipient is immunosuppressed (immunosuppression induced - ongoing) \u2663\tEg calcineurin inhibitors to prevent signalling from T cell receptor to nucleus o\tThere is some acute rejection that is","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197766,"quiz_id":"11772","answer_id":null,"answerType_id":"2","created_at":"2017-05-04 14:29:05","updated_at":"2017-05-04 14:30:26","questionName":"Match up the PHASES of graft vs host disease","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197762,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-04 14:22:16","updated_at":"2017-05-04 14:22:16","questionName":"What is GRAFT VS HOST DISEASE (GVHD)?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"In GvHD, the donated bone marrow or peripheral blood stem cells view the recipient's body as foreign, and the donated cells(\/bone marrow) attack the body.","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":201624,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-11 08:11:16","updated_at":"2017-05-11 08:11:16","questionName":"What is TRUE regarding IMMUNOLOGICALLY PRIVILEGED SITES","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197748,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-04 12:44:20","updated_at":"2017-05-04 12:45:31","questionName":"Why would you DEFINITELY BLOOD MATCH a solid organ before transplant?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"Pre-existing antibody (against blood group antigen) reacts with antigen on vascular endothelium of transplanted organ o\tComplement and coagulation cascades initiated o\tOrgan vessels become blocked o\tOrgan death \u2013 FAST (organ can be destroyed before surger","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197742,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-04 12:26:06","updated_at":"2017-05-04 12:26:06","questionName":"Why is TISSUE TYPING NOT performed before a heart transplant?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"o\tThe chances of finding a heart donor who IS a tissue match are slim o\tTake whatever heart you can \u2013 no time to tissue match o\tFor kidney? \u2663\tMore time, less urgent \u2013 so tissue typing is more likely to be performed \u2663\tOrgans do better when the tissue type ","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197776,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-04 14:43:38","updated_at":"2017-05-04 14:44:16","questionName":"You find a kidney for a patient who desperately needs one - but the patient has a LOT of HLA antibodies against the kidney - WHICH 3 OF THE FOLLOWING WOULD REDUCE REJECTION ?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"Retuximab - removes b cells ","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197738,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-04 12:10:34","updated_at":"2017-05-04 12:10:34","questionName":"Which is NOT a MHC CLASS 1 gene?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"o\tClass I = HLA-A, HLA-B, HLA-C o\tClass II = HLA-DR, HLA-DQ, HLA-DP ","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":197760,"quiz_id":"11772","answer_id":null,"answerType_id":"0","created_at":"2017-05-04 14:16:32","updated_at":"2017-05-04 14:16:32","questionName":"Select which 5 are TRUE regarding CHRONIC REJECTION","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":null,"explanation":"Chronic Rejection -\tSeen more commonly -\tConcentric arteriosclerosis of graft blood vessels - Infiltrative fibrosis -\tAssociated with ischaemia-reperfusion injury -\tRole of alloreactive T cells secreting CCL5 -\tAttracts macrophages, secrete IL-1, TNF -\t","question_score_id":null,"lang":null,"questionAudioPath":null}]
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How many HLA/MHC molecules does each cell express?

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