UoM Immunology Lectures 17-19 (Year 2, Sem 2 2017)

uom-immunology-lectures-17-19-year-2-sem-2-2017

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Question 1 of 1

Time Left

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Tolerance is established as a series of checkpoints. Central tolerance occurs at primary lymphoid organs and is the...

Select the correct answer(s).

(0/0)

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Peripheral tolerance occurs because some self-reactive cells escape the central tolerance, occurring in... peripheral organs/tissues and secondary lymphoid organs

Select the correct answer(s).

(0/0)

204086

600

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In development of B-cells in the bone marrow they go from being stem cells to mature B-cells, order the steps in this development and not the checkpoints involved (an image is provided if needed).

Match the text (click and drag)

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Match the Text
1
2
3
4
5
6
7

Click and drag
Early pro-B cell - Heavy chain D-J rearranging occurs
Small pre-B-cell - Proliferation occurs here. Light chain V-J rearranging occurs.
Mature B-cell - The IgD and IgM made from alternative spliced H-chain transcripts are expressed on the surface
Immature B-cell - Tolerance checkpoint occurs as the IgM is expressed on the surface, allowing binding to self antigens in the bone marrow
Large pre-B cell - This is where the quality checkpoint is (Antigen independent). μ chain transiently expressed at the membrane as part of a receptor (mainly intracellular)
Late pro-B cell - Heavy chain V-DJ rearranging
Stem cell

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The strength of interaction with self-antigens is influenced in 2 ways, choose the incorrect reason.

Select the correct answer(s).

(0/0)

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Immature B-cells in the bone marrow that have no self reaction...

Select the correct answer(s).

(0/0)

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When immature B-cells react to self antigens too strongly, clonal deletion occurs or it is rescued. Cells are rescued when...

Select the correct answer(s).

(0/0)

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Clonally ignorant mature B-cells occur when there is low affinity, non-crosslinking self antigens. Anergic B-cells are produced from immature B-cells when... (a picture is provided if needed)

Select the correct answer(s).

(0/0)

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Central tolerance occurs in T-cells, as well as B-cells. Order the stages in development of T-cells in the thymus (an image is provided if needed).

Match the text (click and drag)

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Match the Text
1
2
3
4

Click and drag
Early thymocyte
Double -ve thymocytes (no CD4 or CD8)
Double +ve thymocytes (CD4 & CD8)
Single +ve thymocytes (CD4 or CD8)

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Match the checkpoints in T-cell development with the order they are in (an image is provided if needed)

Match the text (click and drag)

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Explanation

2% of cell that make structural TCR, make it through thymic selection to enter the periphery

Match the text
1st Checkpoint
2nd Checkpoint
3rd Checkpoint

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Removal of T-cells that recognise self-MHC:self-antigens too strongly
Removal of T-cells that fail to make a functional TCR
Removal of T-cells that cannot recognise self-MHC molecules

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The first checkpoint in T-cell development quality control involves the removal of T-cells without functional TCR-beta. It is described as...

Select the correct answer(s).

(0/0)

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Different developmental checkpoints of T-cells occur at different regions of the thymus. Match the region with the check point (a picture is provided if needed)

Match the text (click and drag)

(0/0)

Match the text
Checkpoint 1 (functional TCR?)
Checkpoint 2 (positive selection, can TCR bind self-MHC?)
Checkpoint 3 (negative selection, does TCR bind self-MHC/antigens too strongly?)

Click and drag
Medulla
Subcapsular Region
Cortex

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120

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If during the checkpoint 2 (positive selection) alpha-TCR undergoes receptor chain editing, if it still cannot recognise self-MHC/self-antigen it dies after...

Select the correct answer(s).

(0/0)

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240

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Cells throughout the body have different cell-surface antigens. During negative selection (checkpoint 3) the Medullary Epithelial cells of the thymus express transcription factors AIRE (AutoImmune REgulator) and Fezf2, which allow expression of genes not normally expressed in the thymus and this is called...

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The strength of TCR signals is thought to determine whether T-cells die, this is called the...

Select the correct answer(s).

(0/0)

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UoM Immunology Lectures 17-19 (Year 2, Sem 2 2017)

Question 1 of 1

Time Left

Tolerance is established as a series of checkpoints. Central tolerance occurs at primary lymphoid organs and is the...

Select the correct answer(s).

(0/0)

Peripheral tolerance occurs because some self-reactive cells escape the central tolerance, occurring in... peripheral organs/tissues and secondary lymphoid organs

Select the correct answer(s).

(0/0)

In development of B-cells in the bone marrow they go from being stem cells to mature B-cells, order the steps in this development and not the checkpoints involved (an image is provided if needed).

Match the text (click and drag)

(0/0)

1

2

3

4

5

6

7

Early pro-B cell - Heavy chain D-J rearranging occurs

Small pre-B-cell - Proliferation occurs here. Light chain V-J rearranging occurs.

Mature B-cell - The IgD and IgM made from alternative spliced H-chain transcripts are expressed on the surface

Immature B-cell - Tolerance checkpoint occurs as the IgM is expressed on the surface, allowing binding to self antigens in the bone marrow

Large pre-B cell - This is where the quality checkpoint is (Antigen independent). μ chain transiently expressed at the membrane as part of a receptor (mainly intracellular)

Late pro-B cell - Heavy chain V-DJ rearranging

Stem cell

The strength of interaction with self-antigens is influenced in 2 ways, choose the incorrect reason.

Select the correct answer(s).

(0/0)

Immature B-cells in the bone marrow that have no self reaction...

Select the correct answer(s).

(0/0)

When immature B-cells react to self antigens too strongly, clonal deletion occurs or it is rescued. Cells are rescued when...

Select the correct answer(s).

(0/0)

Clonally ignorant mature B-cells occur when there is low affinity, non-crosslinking self antigens. Anergic B-cells are produced from immature B-cells when... (a picture is provided if needed)

Select the correct answer(s).

(0/0)

Central tolerance occurs in T-cells, as well as B-cells. Order the stages in development of T-cells in the thymus (an image is provided if needed).

Match the text (click and drag)

(0/0)

1

2

3

4

Early thymocyte

Double -ve thymocytes (no CD4 or CD8)

Double +ve thymocytes (CD4 & CD8)

Single +ve thymocytes (CD4 or CD8)

Match the checkpoints in T-cell development with the order they are in (an image is provided if needed)

Match the text (click and drag)

(0/0)

Explanation

1st Checkpoint

2nd Checkpoint

3rd Checkpoint

Removal of T-cells that recognise self-MHC:self-antigens too strongly

Removal of T-cells that fail to make a functional TCR

Removal of T-cells that cannot recognise self-MHC molecules

The first checkpoint in T-cell development quality control involves the removal of T-cells without functional TCR-beta. It is described as...

Select the correct answer(s).

(0/0)

Different developmental checkpoints of T-cells occur at different regions of the thymus. Match the region with the check point (a picture is provided if needed)

Match the text (click and drag)

(0/0)

Checkpoint 1 (functional TCR?)

Checkpoint 2 (positive selection, can TCR bind self-MHC?)

Checkpoint 3 (negative selection, does TCR bind self-MHC/antigens too strongly?)

Medulla

Subcapsular Region

Cortex

If during the checkpoint 2 (positive selection) alpha-TCR undergoes receptor chain editing, if it still cannot recognise self-MHC/self-antigen it dies after...

Select the correct answer(s).

(0/0)

Select the correct answer(s).

(0/0)

The strength of TCR signals is thought to determine whether T-cells die, this is called the...

Select the correct answer(s).

(0/0)

In peripheral tolerance, self reactive T and B cells enter the periphery and the peripheral tolerance of B-cells is determined by...