UoM Immunology Lectures 11-12 (Year 2, Sem 2 2017)

uom-immunology-lectures-11-15-year-2-sem-2-2017

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Question 1 of 1

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201061

120

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The majority of the innate immune system lineage are of the

lineage.

201072

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Select the myeloid type cell that isn't a granulocyte.

Select the correct answer(s).

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201254

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Because of the short life span of neutrophils, they form a large constituent of...

Select the correct answer(s).

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201346

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In phagocytosis the cell kills the pathogen via acidification as well as enzymes and toxic oxygen species. In neutrophils there is another mechanism, what is that mechanism?

Select the correct answer(s).

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201411

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Eosinophils and Basophils have small amounts of phagocytic activity but mostly act via degranulation toxic granules. Match the cell type with its degranulation products.

Match the text (click and drag)

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Match the text
Eosinophils (2-5% of WBC's)
Basophils (0.2 of WBC's)

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Major basic protein, eosinophil cationic protein
Histamine, prostaglandins, heparin and leukotrienes

201412

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Mast cells are basophil like, found only in the tissue. When mast cells are at rest they bound IgE on its cell surface with high affinity; what happends when IgE binds an antigen?...

Select the correct answer(s).

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201413

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Natural killer cells (NK) interact with abnormal cancerous/infected cells and normal cells. How does it differentiate between the two?

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201899

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There are 3 pathways of complement activation. Order the sequences of the classical pathway (complement binds to antibody/pathogen surface complex).

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Match the Text
1
2
3
4
5

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C1s cleaves C4 into C4a and C4b which binds to microbial surface
C3b molecules accumulate and bind to the microbial surface
C4b2 cleaves C3 to C3a and C3b (C3b binds to the cell surface or convertase itself)
C4b binds to C2 (which is cleaved by C1s to C2a and C2b) forming the C4b2 complex (an active C3 convertase)
C1q binds to pentameric IgM or multiple IgG molecules

201903

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The alternative pathway of complement activation doesn't require antibody and is distinguished by the inclusion of complement B and D. Order the steps in this pathway.

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Match the Text
1
2
3
4
5
6

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Factor B binds C3(H2O)
C3b rapidly inactivates unless it then binds to the cell surface
C3 undergoes spontaneous hydrolysis to C3(H2O)
Bb binds to C3(H2O) to form the C3(H2O)Bb complex
Factor B to be cleaved by factor D into Ba and Bb
The C3(H2O)Bb complex cleaves more C3 (C3 convertase)

201917

600

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The Lectin pathway is the 3rd pathway that complement is activated and acts through mannose binding lectin in serum. Order the steps of the pathway.

Match the text (click and drag)

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Match the Text
1
2
3
4
5
6
7

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MBL associated proteases (MASPS) bind to MBL on the pathogens mannose
C4b binds C2a and forms the C4b2 complex
Mannose on pathogens cell surface is bound to by mannose binding lectin (MBL)
C4b then follows the same route as the classical pathway, cleaving C2 into C2a and C2b
More C3b is generated and binds to a microbial surface
MBL-MASP complex cleaves C4 and C2
C4b2 cleaves C3 to C3a and C3b

201919

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MHC-2 is expressed in...

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Explanation

This complex is associated with CD4+ T-cells, along with costimulation by dendritic cells

201920

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MHC1 is expressed in...

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Explanation

This complex is associated with CD8+ T-cells, along with costimulation by dendritic cells

201921

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Natural killer T-cells or cytotoxic T-cell lymphocytes are formed from...

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201923

300

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Order the steps in how a natural killer (cytotoxic) T-cell kills an infected cell?

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Match the Text
1
2
3

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CTL recognises an antign and reorganises the cytotoxic granules close to the target cell
T-cell binds loosely to a target cells MHC1 antigen complex
Cytotoxic granules are released at the cell-cell contact, allowing specific killing of a target (quick and induces apoptosis)

201924

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Match the contents of a cytotoxic granules with their function.

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Granzymes
Granulysin
Perforin

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Antimicrobial compound that induces apoptosis
Helps deliver the granule contents to target cells
Serine proteases that induces apoptosis

UoM Immunology Lectures 11-12 (Year 2, Sem 2 2017)

Question 1 of 1

Time Left

Fill in the blanks!

Fill in the blanks

(0/0)

Select the myeloid type cell that isn't a granulocyte.

Select the correct answer(s).

(0/0)

Because of the short life span of neutrophils, they form a large constituent of...

Select the correct answer(s).

(0/0)

In phagocytosis the cell kills the pathogen via acidification as well as enzymes and toxic oxygen species. In neutrophils there is another mechanism, what is that mechanism?

Select the correct answer(s).

(0/0)

Eosinophils and Basophils have small amounts of phagocytic activity but mostly act via degranulation toxic granules. Match the cell type with its degranulation products.

Match the text (click and drag)

(0/0)

Eosinophils (2-5% of WBC's)

Basophils (0.2 of WBC's)

Major basic protein, eosinophil cationic protein

Histamine, prostaglandins, heparin and leukotrienes

Mast cells are basophil like, found only in the tissue. When mast cells are at rest they bound IgE on its cell surface with high affinity; what happends when IgE binds an antigen?...

Select the correct answer(s).

(0/0)

Natural killer cells (NK) interact with abnormal cancerous/infected cells and normal cells. How does it differentiate between the two?

Select the correct answer(s).

(0/0)

There are 3 pathways of complement activation. Order the sequences of the classical pathway (complement binds to antibody/pathogen surface complex).

Match the text (click and drag)

(0/0)

1

2

3

4

5

C1s cleaves C4 into C4a and C4b which binds to microbial surface

C3b molecules accumulate and bind to the microbial surface

C4b2 cleaves C3 to C3a and C3b (C3b binds to the cell surface or convertase itself)

C4b binds to C2 (which is cleaved by C1s to C2a and C2b) forming the C4b2 complex (an active C3 convertase)

C1q binds to pentameric IgM or multiple IgG molecules

The alternative pathway of complement activation doesn't require antibody and is distinguished by the inclusion of complement B and D. Order the steps in this pathway.

Match the text (click and drag)

(0/0)

1

2

3

4

5

6

Factor B binds C3(H2O)

C3b rapidly inactivates unless it then binds to the cell surface

C3 undergoes spontaneous hydrolysis to C3(H2O)

Bb binds to C3(H2O) to form the C3(H2O)Bb complex

Factor B to be cleaved by factor D into Ba and Bb

The C3(H2O)Bb complex cleaves more C3 (C3 convertase)

The Lectin pathway is the 3rd pathway that complement is activated and acts through mannose binding lectin in serum. Order the steps of the pathway.

Match the text (click and drag)

(0/0)

1

2

3

4

5

6

7

MBL associated proteases (MASPS) bind to MBL on the pathogens mannose

C4b binds C2a and forms the C4b2 complex

Mannose on pathogens cell surface is bound to by mannose binding lectin (MBL)

C4b then follows the same route as the classical pathway, cleaving C2 into C2a and C2b

More C3b is generated and binds to a microbial surface

MBL-MASP complex cleaves C4 and C2

C4b2 cleaves C3 to C3a and C3b

MHC-2 is expressed in...

Select the correct answer(s).

(0/0)

Explanation

MHC1 is expressed in...

Select the correct answer(s).

(0/0)