UoM Drugs and the Brain Lecture 5-8 Parkinsons, Alzheimers and CNS stimulants (Year 2, Sem 2, 2017)

uom-drugs-and-the-brain-lecture-5-8-parkinsons-alzheimers-and-cns-stimulants-year-2-sem-2-2017

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Its predicted that in 2050 1 in 85 people will have Alzheimers, with the mean life expectancy being 7 years following diagnosis. What is the leading underlying cause of 70% of call cases?

Select the correct answer(s).

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In the CNS dead neurones and damaged nerve terminals are usually not replaced; this leads to possibility for neurodegeneration. What is parkinsons usually NOT characterised by?

Select the correct answer(s).

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As well as the characterisation of parkinsons disease, there are some symptoms that result from them. Choose the incorrect symptom of parkinsons.

Select the correct answer(s).

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Parkinsons is a disease of the Basal ganglia. Choose the area of this that isn't a principle structure to lear.

Select the correct answer(s).

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The basal ganglia is the main target of parkinsons disease, having a role in motor control, learning and mood! It links to the cortex and back, to the thalamus and also the spinal output. What dopaminergic pathway are we therefore interested in with Parkinsons?

Select the correct answer(s).

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The striatum is made up of the caudate nucleus and the putamen. What does this part of the brain look like?

Select the correct answer(s).

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The Basal ganglia thalamocortical circuitry is an important mechanism to understand, taking direct and indirect pathways. Order the steps involved in the more simple, D1 receptor, direct pathway (learn this well).

Match the text (click and drag)

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1
2
3
4

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Thalamocortical excitatory drive is therefore increased from reduced inhibition from the Gpi
Decreased inhibitory output from the Gpi reduces inhibition of thalamic cells
Enhanced inhibitory output from putamen GABAergic cells inhibits Gpi GABAergic cells
Start - Activation of D1 receptors excites GABAergic cells of the putamen

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Ecstasy is described as being on amphetamine and a mild LSD. But which of these isn't an adverse effect of the MDMA?

Select the correct answer(s).

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Convulsants are a category of drug under the stimulatory drugs, inducing seizures in those who take them. There are used as test bed for anti-convulsants, but what is their main action?

Select the correct answer(s).

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262704

180

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Convulsants are a category of drug under the stimulatory drugs, inducing seizures in those who take them. There are used as test bed for anti-convulsants, but what is their main action?

Select the correct answer(s).

(0/0)

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180

none

Penicillin is an anti-GABA drug used to induce seizures in patients, and is usually applied to the cortex/injected for what reason?

Select the correct answer(s).

(0/0)

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240

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Bicuculline and Gabazine are GABAa antagonists (convulsants), used to experimentall induce seizures. What other important use do they have?

Select the correct answer(s).

(0/0)

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240

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There is a convulsant that acts on a ligand gated Cl- receptor (GABAa), and is a Glycine antagonist in the spinal cord. It causes risus sardonicus (seen in pictures) and facial muscle tetany. What is name of the drug described in this case?

Select the correct answer(s).

(0/0)

262708

120

none

Strychnine is a convulsant (Glycine antagonist at GABAa Cl- channel) and an alkaloid from Nux vomica tree seeds. What is a lethal dose of this compound to humans?

Select the correct answer(s).

(0/0)

262709

180

none

Benzodiazepines and some anaesthetics act at glycine receptors (Cl- channel), with others modulating the glycine channel (such as antispasmodics + muscle relaxants). But which toxin is shown to act in the same way, preventing release of glycine and killing the subject?

UoM Drugs and the Brain Lecture 5-8 Parkinsons, Alzheimers and CNS stimulants (Year 2, Sem 2, 2017)

Question 1 of 1

Time Left

Its predicted that in 2050 1 in 85 people will have Alzheimers, with the mean life expectancy being 7 years following diagnosis. What is the leading underlying cause of 70% of call cases?

Select the correct answer(s).

(0/0)

In the CNS dead neurones and damaged nerve terminals are usually not replaced; this leads to possibility for neurodegeneration. What is parkinsons usually NOT characterised by?

Select the correct answer(s).

(0/0)

As well as the characterisation of parkinsons disease, there are some symptoms that result from them. Choose the incorrect symptom of parkinsons.

Select the correct answer(s).

(0/0)

Parkinsons is a disease of the Basal ganglia. Choose the area of this that isn't a principle structure to lear.

Select the correct answer(s).

(0/0)

The basal ganglia is the main target of parkinsons disease, having a role in motor control, learning and mood! It links to the cortex and back, to the thalamus and also the spinal output. What dopaminergic pathway are we therefore interested in with Parkinsons?

Select the correct answer(s).

(0/0)

The striatum is made up of the caudate nucleus and the putamen. What does this part of the brain look like?

Select the correct answer(s).

(0/0)

The Basal ganglia thalamocortical circuitry is an important mechanism to understand, taking direct and indirect pathways. Order the steps involved in the more simple, D1 receptor, direct pathway (learn this well).

Match the text (click and drag)

(0/0)

1

2

3

4

Thalamocortical excitatory drive is therefore increased from reduced inhibition from the Gpi

Decreased inhibitory output from the Gpi reduces inhibition of thalamic cells

Enhanced inhibitory output from putamen GABAergic cells inhibits Gpi GABAergic cells

Start - Activation of D1 receptors excites GABAergic cells of the putamen

Ecstasy is described as being on amphetamine and a mild LSD. But which of these isn't an adverse effect of the MDMA?

Select the correct answer(s).

(0/0)

Convulsants are a category of drug under the stimulatory drugs, inducing seizures in those who take them. There are used as test bed for anti-convulsants, but what is their main action?

Select the correct answer(s).

(0/0)

Convulsants are a category of drug under the stimulatory drugs, inducing seizures in those who take them. There are used as test bed for anti-convulsants, but what is their main action?

Select the correct answer(s).

(0/0)

Penicillin is an anti-GABA drug used to induce seizures in patients, and is usually applied to the cortex/injected for what reason?

Select the correct answer(s).

(0/0)

Bicuculline and Gabazine are GABAa antagonists (convulsants), used to experimentall induce seizures. What other important use do they have?

Select the correct answer(s).

(0/0)

There is a convulsant that acts on a ligand gated Cl- receptor (GABAa), and is a Glycine antagonist in the spinal cord. It causes risus sardonicus (seen in pictures) and facial muscle tetany. What is name of the drug described in this case?

Select the correct answer(s).

(0/0)

Strychnine is a convulsant (Glycine antagonist at GABAa Cl- channel) and an alkaloid from Nux vomica tree seeds. What is a lethal dose of this compound to humans?

Select the correct answer(s).

(0/0)

Benzodiazepines and some anaesthetics act at glycine receptors (Cl- channel), with others modulating the glycine channel (such as antispasmodics + muscle relaxants). But which toxin is shown to act in the same way, preventing release of glycine and killing the subject?

Select the correct answer(s).

(0/0)

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