UoM Drugs and the Brain Lecture 16-17 Epilepsy and Anticonvulsants (Year 2, Sem 2, 2017)

uom-drugs-and-the-brain-lecture-16-17-epilepsy-and-anticonvulsants-year-2-sem-2-2017

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Question 1 of 1

Time Left

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240

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Tonic clonic seizures are the classic epilepsy, giving 4 stages (sometimes) then post ictal sleep. It sometimes starts with aura, then tonic, then clonic. So match the phase with its characteristics.

Match the text (click and drag)

(0/0)

Match the text
Aura
Tonic
Clonic
Post ictal sleep

Click and drag
Convulsions, incontinence that lasts several minutes
Confusion and illness when regaining consciousness
Psychic symptoms of alterned sensory percepton, hallucinations and is a focal seizure with maintained consiousness (warns the person of onset)
Muscle rigidity and vocalizations

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Status epilpeticus is a condition of repeated seizures lasting above 5 minutes and is life threatening, resulting in permanent brain damage. What is the mortality rate percentage of status epilepticus?

Select the correct answer(s).

(0/0)

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120

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Status epilpeticus is a condition of repeated seizures lasting above 5 minutes and is life threatening, resulting in permanent brain damage. What is the mortality rate percentage of status epilepticus?

Select the correct answer(s).

(0/0)

263939

180

none

There are 5 ways of classifying epilepsy. The type, age on onset, Aetiology, triggers and the brain areas involved. Which isn't a age used for classification?

Select the correct answer(s).

(0/0)

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180

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There are 5 ways of classifying epilepsy. Type, age at onset, aetiology, triggers and brain areas involved. Which of these isn't a aetiology classification?

Select the correct answer(s).

(0/0)

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180

none

There are 5 classifications for epilepsy, one being the trigger (most are spontaneous, with stress increasing frequency). There are some particular triggers, which isn't a common or even rare trigger?

Select the correct answer(s).

(0/0)

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240

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In classification the area of the brain is used and is often just included in the name of the patients epilepsy. What are most genetic epilepsies have mutations in?

Select the correct answer(s).

(0/0)

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180

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Juvenile myoclonic epilepsy is a common inherited epilepsy (10%), giving absence/tonic-clonic seizures in conjunction. What is a common trigger associated with exam season at University?

Select the correct answer(s).

(0/0)

263944

180

none

There is a weird common syndrome called Startle syndrome that causes drop seizures, caused by mutations in glycinergic transmission (GlyrineR subunits, transporter, cytoskeletal proteins). What is the name of this weird phenomena?

Select the correct answer(s).

(0/0)

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240

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There are 4 main mechanisms for anticonvulsant drugs (shown in picture). Guess the anti-convulsant! It blocks Na+v channels and GABAa receptors, is first line for tonic-clonic seizures and also used as a mood stabiliser in bipolar and neuropathic pain. Its related to Oxycarbazepine, and acts by auto inducing CYP3A4. Side effects are teratogenic, lupus, cognitive issues.

Select the correct answer(s).

(0/0)

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180

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Guess the anti-convulsant! Sodium channel blocker, first line for tonic-clonic seizures and 2nd line for absence, but can exacerbate myoclonic seizures. Can treat bipolar disorder, giving side effects of sedation, sleep disturbance, rash and binding eye pigment.

Select the correct answer(s).

(0/0)

263947

240

none

Phenytoin is related to barbiturates, stabilising Na+v channels in an inactivated state. Great for all epilepsy but absence seizures and is no longer first line. Teratogenic, lupus, cerebellar atrophy, acne and gingival overgrowth.

Select the correct answer(s).

(0/0)

263949

240

none

Guess the anticonvulsant! Its structure is similar to GABA, acting on the alpha2 delta subunit of calcium channel. It increases GAD levels to raise synthesis. Good for neuropathic pain and anxiety

Select the correct answer(s).

(0/0)

263950

240

none

Guess the anticonvulsant! Its structure is similar to GABA, acting on the alpha2 delta subunit of calcium channel. It increases GAD levels to raise synthesis. Good for neuropathic pain and anxiety. Sedation, dizziness, suicidal thoughts, seizures on withdrawl, controversy.

Select the correct answer(s).

(0/0)

263951

240

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Guess the anticonvulsant drug! It is the first line for absense seizures, blocking T-type calcium channels, gives no liver toxicity. Side effects are sedation and nausea.

UoM Drugs and the Brain Lecture 16-17 Epilepsy and Anticonvulsants (Year 2, Sem 2, 2017)

Question 1 of 1

Time Left

Tonic clonic seizures are the classic epilepsy, giving 4 stages (sometimes) then post ictal sleep. It sometimes starts with aura, then tonic, then clonic. So match the phase with its characteristics.

Match the text (click and drag)

(0/0)

Aura

Tonic

Clonic

Post ictal sleep

Convulsions, incontinence that lasts several minutes

Confusion and illness when regaining consciousness

Psychic symptoms of alterned sensory percepton, hallucinations and is a focal seizure with maintained consiousness (warns the person of onset)

Muscle rigidity and vocalizations

Status epilpeticus is a condition of repeated seizures lasting above 5 minutes and is life threatening, resulting in permanent brain damage. What is the mortality rate percentage of status epilepticus?

Select the correct answer(s).

(0/0)

Status epilpeticus is a condition of repeated seizures lasting above 5 minutes and is life threatening, resulting in permanent brain damage. What is the mortality rate percentage of status epilepticus?

Select the correct answer(s).

(0/0)

There are 5 ways of classifying epilepsy. The type, age on onset, Aetiology, triggers and the brain areas involved. Which isn't a age used for classification?

Select the correct answer(s).

(0/0)

There are 5 ways of classifying epilepsy. Type, age at onset, aetiology, triggers and brain areas involved. Which of these isn't a aetiology classification?

Select the correct answer(s).

(0/0)

There are 5 classifications for epilepsy, one being the trigger (most are spontaneous, with stress increasing frequency). There are some particular triggers, which isn't a common or even rare trigger?

Select the correct answer(s).

(0/0)

In classification the area of the brain is used and is often just included in the name of the patients epilepsy. What are most genetic epilepsies have mutations in?

Select the correct answer(s).

(0/0)

Juvenile myoclonic epilepsy is a common inherited epilepsy (10%), giving absence/tonic-clonic seizures in conjunction. What is a common trigger associated with exam season at University?

Select the correct answer(s).

(0/0)

There is a weird common syndrome called Startle syndrome that causes drop seizures, caused by mutations in glycinergic transmission (GlyrineR subunits, transporter, cytoskeletal proteins). What is the name of this weird phenomena?

Select the correct answer(s).

(0/0)

Select the correct answer(s).

(0/0)

Guess the anti-convulsant! Sodium channel blocker, first line for tonic-clonic seizures and 2nd line for absence, but can exacerbate myoclonic seizures. Can treat bipolar disorder, giving side effects of sedation, sleep disturbance, rash and binding eye pigment.

Select the correct answer(s).

(0/0)

Phenytoin is related to barbiturates, stabilising Na+v channels in an inactivated state. Great for all epilepsy but absence seizures and is no longer first line. Teratogenic, lupus, cerebellar atrophy, acne and gingival overgrowth.

Select the correct answer(s).

(0/0)

Guess the anticonvulsant! Its structure is similar to GABA, acting on the alpha2 delta subunit of calcium channel. It increases GAD levels to raise synthesis. Good for neuropathic pain and anxiety

Select the correct answer(s).

(0/0)

Guess the anticonvulsant! Its structure is similar to GABA, acting on the alpha2 delta subunit of calcium channel. It increases GAD levels to raise synthesis. Good for neuropathic pain and anxiety. Sedation, dizziness, suicidal thoughts, seizures on withdrawl, controversy.

Select the correct answer(s).

(0/0)

Guess the anticonvulsant drug! It is the first line for absense seizures, blocking T-type calcium channels, gives no liver toxicity. Side effects are sedation and nausea.

Select the correct answer(s).

(0/0)

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