UoM Cell Metabolism Lecture 5-10 Carbohydrates (Year 2, Sem 2, 2017)

uom-cell-metabolism-lecture-5-10-sem-2-2017

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Question 1 of 1

Time Left

194373

120

block

Glucokinase is made inactive by nuclear sequestration via Glucokinase regulatory protein (GRP). Which molecule regulate active and inactive forms of GK?

Select the correct answer(s).

(0/0)

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Glucose-6-Phosphatase is regulated by...

Select the correct answer(s).

(0/0)

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G6Pase is located on the internal surface of endosomes. Match the relevant translocase with its function.

Match the text (click and drag)

(0/0)

Match the text
Translocase T1
Translocase T2
Translocase T3

Click and drag
Translocate phosphate out of the endosome, after G6Pase catalysis
Translocate glucose out of the endosome, after G6Pase catalysis
Translocate G6P into the endosome, before G6Pase catalysis

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There are two types of Glucose Storage Disease (GSD), match the mutation to the type

Match the text (click and drag)

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Match the text
Type 1a
Type 1b

Click and drag
Mutation in Translocase T1 (Moves G6P into the cell)
Mutation in G6Pase

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G6Pase is regulated by translocation in the endosome and transcriptional regulation (it does have other ways, but they arn't explored in the lectures). Which protein is essential for transcription of G6Pase?

Select the correct answer(s).

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194484

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How is Foxo1a regulated?

Select the correct answer(s).

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Explanation

This protein regulates G6Pase transcription

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Phosphofructokinase (PFK) and ATP catalyses...

Select the correct answer(s).

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Fructose-1,6-Bisphosphatase (F16BPase) catalyses...

Select the correct answer(s).

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PFK...

Select the correct answer(s).

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Fructose-1,6-Bisphosphatase (F16BPase) exists in...

Select the correct answer(s).

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194589

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PFK is allosterically regulated. Match the molecules to the action...

Match the text (click and drag)

(0/0)

Match the text
Inhibition (Shows low energy output)
Stimulation (Shows high energy output))

Click and drag
AMP, ADP, Pi
ATP

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Phosphofructokinase exists as PFK-1 and PFK-2, match the isoenzyme with its function

Match the text (click and drag)

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Match the text
PFK-1
PFK-2

Click and drag
F6P --> F26BP
F6P --> F16BP

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What is the correct order of the Glucose metabolism pathway? (ignoring the multiple directions)

Match the text (click and drag)

(0/0)

Match the Text
1
2
3
4
5
6
7
8
9

Click and drag
OxaloAcetate then Amino Acids OR Acetyl CoA then Citric Acid cycle or Lipids
Intracellular Glucose
Fructose-6-phosphate (F6P) (or Pentose Sugar or Glycogen)
Phosphoenolpyruvate carboxylase (PEP) (or Lipids)
Glucose-6-Phosphate (G6P)
Extracellular Glucose
Pyruvate in Cytosol
Fructose-1,6-Bisphosphate (F16BP)
Pyruvate in Mitochondria

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In a Starved state... (Image is provided if you are stuck)

Select the correct answer(s).

(0/0)

193972

600

none

UoM Cell Metabolism Lecture 5-10 Carbohydrates (Year 2, Sem 2, 2017)

Question 1 of 1

Time Left

Glucokinase is made inactive by nuclear sequestration via Glucokinase regulatory protein (GRP). Which molecule regulate active and inactive forms of GK?

Select the correct answer(s).

(0/0)

Glucose-6-Phosphatase is regulated by...

Select the correct answer(s).

(0/0)

G6Pase is located on the internal surface of endosomes. Match the relevant translocase with its function.

Match the text (click and drag)

(0/0)

Translocase T1

Translocase T2

Translocase T3

Translocate phosphate out of the endosome, after G6Pase catalysis

Translocate glucose out of the endosome, after G6Pase catalysis

Translocate G6P into the endosome, before G6Pase catalysis

There are two types of Glucose Storage Disease (GSD), match the mutation to the type

Match the text (click and drag)

(0/0)

Type 1a

Type 1b

Mutation in Translocase T1 (Moves G6P into the cell)

Mutation in G6Pase

G6Pase is regulated by translocation in the endosome and transcriptional regulation (it does have other ways, but they arn't explored in the lectures). Which protein is essential for transcription of G6Pase?

Select the correct answer(s).

(0/0)

How is Foxo1a regulated?

Select the correct answer(s).

(0/0)

Explanation

Phosphofructokinase (PFK) and ATP catalyses...

Select the correct answer(s).

(0/0)

Fructose-1,6-Bisphosphatase (F16BPase) catalyses...

Select the correct answer(s).

(0/0)

PFK...

Select the correct answer(s).

(0/0)

Fructose-1,6-Bisphosphatase (F16BPase) exists in...

Select the correct answer(s).

(0/0)

PFK is allosterically regulated. Match the molecules to the action...

Match the text (click and drag)

(0/0)

Inhibition (Shows low energy output)

Stimulation (Shows high energy output))

AMP, ADP, Pi

ATP

Phosphofructokinase exists as PFK-1 and PFK-2, match the isoenzyme with its function

Match the text (click and drag)

(0/0)

PFK-1

PFK-2

F6P --> F26BP

F6P --> F16BP

What is the correct order of the Glucose metabolism pathway? (ignoring the multiple directions)

Match the text (click and drag)

(0/0)

1

2

3

4

5

6

7

8

9

OxaloAcetate then Amino Acids OR Acetyl CoA then Citric Acid cycle or Lipids

Intracellular Glucose

Fructose-6-phosphate (F6P) (or Pentose Sugar or Glycogen)

Phosphoenolpyruvate carboxylase (PEP) (or Lipids)

Glucose-6-Phosphate (G6P)

Extracellular Glucose

Pyruvate in Cytosol

Fructose-1,6-Bisphosphate (F16BP)

Pyruvate in Mitochondria

In a Starved state... (Image is provided if you are stuck)