UoM Cell Metabolism Lecture 11-15 Lipids and Plant Lipids (Year 2, Sem 2, 2017)

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Question 1 of 1

Time Left

264976

240

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HSL (Forms DAG from TAG and MAG from DAG) is inhibited in a fed state by insulin and stimulated in a starved/exercised state by adrenaline. Match the phosphorylation state with its activity.

Match the text (click and drag)

(0/0)

Match the text
Phosphorylated
Dephosphorylated

Click and drag
Inactive (Insulin)
Active (by adrenaline)

264992

240

none

Adipose triglyceride lipase (used alongside HSL in forming DAG from TAG). We know it is highly expressed in adipose tissue, but match the coarse/fine control with its characteristics.

Match the text (click and drag)

(0/0)

Match the text
Fasting/exercise induced hormone molecules (coarse
Fed state hormone molecules (coarse)
AMPK (fine)
CGL-58 regulatory protein (fine)

Click and drag
Inhibited
Phosphorylates to activate short term
Activated short term
Stimulated

264993

360

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In adipocytes lipolysis is a very coordinated regulation process, which is rapid and serves to amplify the signal. Order the steps involved in adipoxyte lipolysis (Includes a new molecule).

Match the text (click and drag)

(0/0)

Match the Text
1
2
3

Click and drag
Activation of PKA, phosphorylation of HSL and perilipin
Recruitment of HSL (to perilipin), release of CGL-58 which activates ATGL
Lipolytic signal (adrenaline)

264994

240

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Lipoproteins are important for transport of lipids between organs or tissues. Which of these statements about lipoprotein structure is incorrect?

Select the correct answer(s).

(0/0)

264999

480

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TAG can't typically enter through lipid membranes and are therefore converted into fatty acids when needing to cross membranes. Order the steps involved in digestion and transport of dietary lipids.

Match the text (click and drag)

(0/0)

Match the Text
1
2
3
4
5
6
7
8

Click and drag
Bile salts emulsify small intestine far forming mixed micelles
The intestinal mucosa converts fatty acids and other breakdown products back into TAG's
Lipoprotein lipase activate by apoC in capillaries (converts TAG's to FA's and glycerol)
Chylomicrons move through the lymphatics/bloodstream to tissues
TAG's incorporated with cholestrol and apolipoproteins into chylomicrons
Fatty acids enter cells
Intestinal lipases degrade TAG's
Fatty acids are oxidised for fuel or reesterified to TAG for storage

265017

240

none

Match the type of lipoprotein with its core lipids, apolipoproteins and mechanism of delivery.

Match the text (click and drag)

(0/0)

Match the text
Chylomicron
VLDL
LDL
HDL

Click and drag
Endogenous TAG's, apolipoproteins B-100, C, E, delivery via hydrolysis by lipoprotein lipase
Hold dietary TAG's, apolipoproteins B-48, C, E, delivery via hydrolysis by lipoprotein lipase
Endogenous cholestrol esters, apolipoproteins B-100, receptor mediated endocytosis to liver and other tissues
Endogenous cholesterol esters, apolipoproteins A, transfer of cholestrol esters to IDL and LDL

265018

240

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Apolipoproteins are different in each lipoprotein vesicle, but what does ApoB100 do (present chiefly on LDL)?

Select the correct answer(s).

(0/0)

265019

240

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When look at apolipoproteins, ApoC binds lipoprotein lipase in muscle/adipose, allowing lipolysis of TAG and release of FA's. Which of these have this apolipiprotein?

Select the correct answer(s).

(0/0)

265020

240

none

Match the type of cells with its activity at fasting and fed states.

Match the text (click and drag)

(0/0)

Match the text
Fasting
Fed

Click and drag
Low muscle activity and high adipose acitivity
High muscle activity and low adipose activity

265022

240

none

Lipid movement across the membrane requires the fat to be in fatty acid form. Match the fatty acid transporters with its tissue distribution and characteristics.

Match the text (click and drag)

(0/0)

Match the text
FAT (fatty acid translocase)
FATP1-6 (fatty acid transporter protein)
FABPpm (fatty acid binding protein plamalemma)

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Widespread, associated with fatty acyl-CoA synthetase
Widespread, recruits FA to plasmamembrane
Adipose/heart/skeletal, translocates from intracellular vesicle to plasmalemma

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300

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The mitochondrial cartinine shuttle is important for taking fatty acids into the mitochondria (after release of FA's from TAG and FA uptake by transport proteins). Order the steps in transfer for FA's across the membrane and recovery of cartinine after use.

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Match the Text
1
2
3
4

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Cartinine acyltransferase 2 removes the fatty acid chain from cartinine ands adds it to acyl-CoA
The fatty acyl CoA is beta-oxidised and the cartinine is sent back to the cytosol
Fatty acyl CoA removes its CoA molecule and attaches the chain to the cartinine molecule by cartinine acyltransferase
The cartinine transporter takes caritine to the mitochondrial matrix

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Which isoform of ACC exists largely (but not exclusively) in non-lipogenic tissues also present in adipose and liver?

Select the correct answer(s).

(0/0)

264810

240

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Fuel and energy storage and reasons for fat storage, and the oxidation of it yields energy. There are 8 major classes of biological lipids, which of them do we need to learn and are important in this course?

Select the correct answer(s).

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265066

240

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ACC2 has similar regulation mechanisms to ACC1 (phosphorylation and citrate). The difference between the two is the additional 114aa N-terminus sequence. ACC1 is located in the cytosol for FA synthesis, but where is ACC2 located for its regulation of FA oxidation?

Select the correct answer(s).

(0/0)

264811

300

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UoM Cell Metabolism Lecture 11-15 Lipids and Plant Lipids (Year 2, Sem 2, 2017)

Question 1 of 1

Time Left

HSL (Forms DAG from TAG and MAG from DAG) is inhibited in a fed state by insulin and stimulated in a starved/exercised state by adrenaline. Match the phosphorylation state with its activity.

Match the text (click and drag)

(0/0)

Phosphorylated

Dephosphorylated

Inactive (Insulin)

Active (by adrenaline)

Adipose triglyceride lipase (used alongside HSL in forming DAG from TAG). We know it is highly expressed in adipose tissue, but match the coarse/fine control with its characteristics.

Match the text (click and drag)

(0/0)

Fasting/exercise induced hormone molecules (coarse

Fed state hormone molecules (coarse)

AMPK (fine)

CGL-58 regulatory protein (fine)

Inhibited

Phosphorylates to activate short term

Activated short term

Stimulated

In adipocytes lipolysis is a very coordinated regulation process, which is rapid and serves to amplify the signal. Order the steps involved in adipoxyte lipolysis (Includes a new molecule).

Match the text (click and drag)

(0/0)

1

2

3

Activation of PKA, phosphorylation of HSL and perilipin

Recruitment of HSL (to perilipin), release of CGL-58 which activates ATGL

Lipolytic signal (adrenaline)

Lipoproteins are important for transport of lipids between organs or tissues. Which of these statements about lipoprotein structure is incorrect?

Select the correct answer(s).

(0/0)

TAG can't typically enter through lipid membranes and are therefore converted into fatty acids when needing to cross membranes. Order the steps involved in digestion and transport of dietary lipids.

Match the text (click and drag)

(0/0)

1

2

3

4

5

6

7

8

Bile salts emulsify small intestine far forming mixed micelles

The intestinal mucosa converts fatty acids and other breakdown products back into TAG's

Lipoprotein lipase activate by apoC in capillaries (converts TAG's to FA's and glycerol)

Chylomicrons move through the lymphatics/bloodstream to tissues

TAG's incorporated with cholestrol and apolipoproteins into chylomicrons

Fatty acids enter cells

Intestinal lipases degrade TAG's

Fatty acids are oxidised for fuel or reesterified to TAG for storage

Match the type of lipoprotein with its core lipids, apolipoproteins and mechanism of delivery.

Match the text (click and drag)

(0/0)

Chylomicron

VLDL

LDL

HDL

Endogenous TAG's, apolipoproteins B-100, C, E, delivery via hydrolysis by lipoprotein lipase

Hold dietary TAG's, apolipoproteins B-48, C, E, delivery via hydrolysis by lipoprotein lipase

Endogenous cholestrol esters, apolipoproteins B-100, receptor mediated endocytosis to liver and other tissues

Endogenous cholesterol esters, apolipoproteins A, transfer of cholestrol esters to IDL and LDL

Apolipoproteins are different in each lipoprotein vesicle, but what does ApoB100 do (present chiefly on LDL)?

Select the correct answer(s).

(0/0)

When look at apolipoproteins, ApoC binds lipoprotein lipase in muscle/adipose, allowing lipolysis of TAG and release of FA's. Which of these have this apolipiprotein?

Select the correct answer(s).

(0/0)

Match the type of cells with its activity at fasting and fed states.

Match the text (click and drag)

(0/0)

Fasting

Fed

Low muscle activity and high adipose acitivity

High muscle activity and low adipose activity

Lipid movement across the membrane requires the fat to be in fatty acid form. Match the fatty acid transporters with its tissue distribution and characteristics.

Match the text (click and drag)

(0/0)

FAT (fatty acid translocase)