Stage 4 CSIM2 - MAID Quiz

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0 [{"id":630554,"quiz_id":"29907","answer_id":null,"answerType_id":"2","created_at":"2018-11-28 10:10:52","updated_at":"2018-11-30 15:01:02","questionName":"Match the term to the correct answer...","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":13,"explanation":"o\tHypertrophy: increase in size of individual cells\r\no\tHyperplasia: increase in number of cells\r\no\tMetaplasia: replacement of one fully differentiated tissue by another\r\n\uf0a7\tUsually a response to persistent injury\r\n\uf0a7\tReverts to original cell type if source of injury is removed\r\no\tDysplasia: Pre-cancerous changes in architectural and cytological structures\r\no\tMAY revert to normal if source of injury is removed","question_score_id":null,"lang":"","questionAudioPath":null},{"id":630548,"quiz_id":"29907","answer_id":null,"answerType_id":"0","created_at":"2018-11-28 09:58:56","updated_at":"2018-11-30 15:01:02","questionName":"Which one of these statements is incorrect regarding oncogenes?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":9,"explanation":"\u2022\tOncogenes:\r\no\tMutated proto-oncogenes\r\no\tPromote proliferation (being over-activated, or insensitive to inactivation)\r\no\tEncode GFs, GF receptors, signal transducers, TFs etc.\r\no\tGAIN OF FUNCTION \u2013 only one copy needed (dominant)","question_score_id":null,"lang":"","questionAudioPath":null},{"id":629763,"quiz_id":"29907","answer_id":null,"answerType_id":"0","created_at":"2018-11-27 12:57:54","updated_at":"2018-11-30 15:01:02","questionName":"Cell to cell linkage of plasma membrane attached proteins e.g. contact inhibition of cell growth (lost in cancer) - which term does this best describe?\r\n","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":2,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":629768,"quiz_id":"29907","answer_id":null,"answerType_id":"0","created_at":"2018-11-27 13:01:09","updated_at":"2018-11-30 15:01:02","questionName":"What types of molecules are the following: Ca2+, DG, ceramide, IP3, cAMP, cGMP, Ras, JAK and REF?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":4,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":629764,"quiz_id":"29907","answer_id":null,"answerType_id":"0","created_at":"2018-11-27 12:57:59","updated_at":"2018-11-30 15:01:02","questionName":"Cell to cell linkage of plasma membrane attached proteins e.g. contact inhibition of cell growth (lost in cancer) - which term does this best describe?\r\n","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":3,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":630556,"quiz_id":"29907","answer_id":null,"answerType_id":"2","created_at":"2018-11-28 10:19:03","updated_at":"2018-11-30 15:01:02","questionName":"Match the type of therapy with the correct corresponding pathway that cancer exploits...","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":"volume-1\/stage-4-csim4-quiz-1\/Cancer targets.png","position":14,"explanation":"B= CDKI\r\nC = IAACM\r\nD= TI\r\nE= SAID\r\nF= IHCF\/c-Met","question_score_id":null,"lang":"","questionAudioPath":null},{"id":629785,"quiz_id":"29907","answer_id":null,"answerType_id":"0","created_at":"2018-11-27 13:24:02","updated_at":"2018-11-30 15:01:02","questionName":"A patient is diagnosed with nephrogenic syndrome of inappropriate antidiuresis (NSIAD) after investigations revealed euvolemic hyponatremia, plasma hypo-osmolality, and increased urinary osmolality. Which receptor is mutated for the gain of function and which amino acid is altered?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":11,"explanation":"Vasopressin receptors (G-protein system)\r\n\u2022\tGene responsible is V2R\r\n\u2022\tIf you have a mutation that inactivates it, you can\u2019t respond to vasopressin\r\no\tCan\u2019t retain water\r\n\u2022\tIf you modify the 137th amino acid and GAIN function in the gene, the vasopressin receptor may be switched on all the time\r\no\tGet excessive water retention (nephrogenic syndrome of inappropriate antidiuresis \u2013 NSIAD)","question_score_id":null,"lang":"","questionAudioPath":null},{"id":630549,"quiz_id":"29907","answer_id":null,"answerType_id":"0","created_at":"2018-11-28 10:03:13","updated_at":"2018-11-30 15:01:02","questionName":"Which of these states is INCORRECT regarding tumour suppressor genes?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":10,"explanation":"\u2022\tTumour suppressor genes:\r\no\tMutation in cells that inhibit proliferation\r\no\tCan be cell cycle control genes, DNA repair genes, apoptosis promotion or telomerase regulation genes\r\no\tLOSS OF FUNCTION mutations \u2013 both copies needed, as the other one can make up for it (recessive)\r\n\uf0a7\tSo in sporadic cancers, both gene copies in the same cell must be lost by mutation\r\no\tIn inherited cancers\u2026\r\n\uf0a7\tone defective copy is inherited as a germline mutation (\u201cfirst hit\u201d)\r\n\uf0a7\tsecond becomes ineffective through somatic mutation (\u201csecond hit\u201d)","question_score_id":null,"lang":"","questionAudioPath":null},{"id":629779,"quiz_id":"29907","answer_id":null,"answerType_id":"0","created_at":"2018-11-27 13:17:11","updated_at":"2018-11-30 15:01:02","questionName":"What do EGFR1, HER2, Erb3 and VEGF all have in common?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":8,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":629770,"quiz_id":"29907","answer_id":null,"answerType_id":"2","created_at":"2018-11-27 13:02:39","updated_at":"2018-11-30 15:01:02","questionName":"Match these molecules to their correct category...","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":5,"explanation":"\u2022\tSecond messenger molecules transmit the signal into the cell\r\no\tSecond messengers can be\u2026\r\n\uf0a7\tIons \u2013 Ca2+\r\n\uf0a7\tLipid derivatives \u2013 DG, ceramide\r\n\uf0a7\tCarbohydrate derivatives \u2013 IP3\r\n\uf0a7\tNucleotides \u2013 cAMP, cGMP\r\n\uf0a7\tProteins \u2013 Ras, JAK, Raf","question_score_id":null,"lang":"","questionAudioPath":null},{"id":629772,"quiz_id":"29907","answer_id":null,"answerType_id":"0","created_at":"2018-11-27 13:09:31","updated_at":"2018-11-30 15:01:02","questionName":"Which of these is a direct ligand-gated channel?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":6,"explanation":"Direct ligand-gated channel\r\n\r\n\u2022\tReceptor changes shape and acts as a channel to let specific molecules through\r\n\u2022\tMay be by facilitated diffusion or active transport\r\n\u2022\tChannels may be uniporters, symporters, or antiporters\r\n\u2022\tUsually by ATPase\r\no\tNicotinic acetylcholine\r\no\tGABA receptors\r\no\tNeurotransmitters\r\n\r\nThe others are all examples of G-protein coupled receptors","question_score_id":null,"lang":"","questionAudioPath":null},{"id":629760,"quiz_id":"29907","answer_id":null,"answerType_id":"0","created_at":"2018-11-27 12:55:15","updated_at":"2018-11-30 15:01:02","questionName":"Cell secretes a substance that acts directly on a neighbouring cell - what is this a description of?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":0,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":630553,"quiz_id":"29907","answer_id":null,"answerType_id":"0","created_at":"2018-11-28 10:07:49","updated_at":"2018-11-30 15:01:02","questionName":"In cancer growth there is a balance between cell gain and cell loss, as the cancer increases in size, it's growth rate slows (number of resting cells increases). What is the name for this type of growth?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":12,"explanation":"Discovered by Benjamin Gompertz, a nineteenth-century actuary, the Gompertzian growth curve describes the complex pattern of tumor growth. The curve has an early, almost exponential growth rate followed by slower growth rate which reaches a plateau as tumors grow larger in size.","question_score_id":null,"lang":"","questionAudioPath":null},{"id":630546,"quiz_id":"29907","answer_id":null,"answerType_id":"0","created_at":"2018-11-28 09:51:52","updated_at":"2018-11-30 15:01:02","questionName":"Which of the following cancers does smoking seem to be protective for?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":7,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":629762,"quiz_id":"29907","answer_id":null,"answerType_id":"0","created_at":"2018-11-27 12:56:30","updated_at":"2018-11-30 15:01:02","questionName":"Cell secretes a substance that acts on itself (stimulation or inhibition) - which term does this best describe?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":1,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null}]
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Match the term to the correct answer...

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Hypertrophy

Hyperplasia

Metaplasia

Dysplasia

Neoplasia

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The presence or formation of new, abnormal growth of tissue

Increase in size of individual cells

Replacement of one fully differentiated tissue by another

Pre-cancerous changes in architectural and cytological structures

Increase in number of cells


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