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Receptor Tyrosine Kinases (RTKs)

receptor-tyrosine-kinases-rtks

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What RAS family has involvement in cellular migration and shape organisation?

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Ras can lead to the activation of Rac by activating...

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Put the stages of Pl3-K activation in order

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Proteins with PH domains targeted (e.g PDK1 and Akt)
Pl3-K binds to RTK via SH2 domain
PIP-3 generated
PIP-2 phosphorylated
Ligand binds to RTK
RTK activated and dimerises

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What gene is transcribed at the end of the MAPK signalling pathways?

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RTKs are what type of receptors?

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On the intercellular region of RTKs is a ___ binding region

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RAS is a...

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Explanation

It is a GTPase as it is regulated by GTP/GDP

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What domain must protein have to bind onto phosphorylated tyrosines?

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Sos binds onto Grb2 due to what domain of Grb2?

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SH3 domains binds on ___-rich region on target proteins

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Sos is what type of molecule?

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The ligand binding extracellular domain of RTKs is rich in ___ domains

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Put the MAPK signalling pathway in order

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p90RSK phosphorylated
MAPK phosphorylated
fos gene transcribed
MEK phosphorylated
Grb2 binding via SH2 domain
MAPK enters nucleus
TCF phosphorylated by MAPK, SAF phosphorylated by active p90RSK
TCF + 2SRF trimer
Removal of 14-3-3 adapted protein
Tyrosine kinase domain phosphorylated
Serum response element activated (SRE) on DNA
Raf activated
Dimerisation of RTKs
RAS activated via exchange of GDP to GTP
Sos binding via SH3 domain
2 MAPK dimerises
EGF binds to EGFR

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