hypothesis is based on the assumption that common disease causing

are found in the population with said disease. The hypothesis stats that the (genotypes, variants)

in these alleles that lead to susceptibilty and different expressions of said disease

within pre-specified genes of interests (candidates!) and

and disease symptoms. These candidates are usually based off of already known

- eg serotonin genes in depression (as lack of serotonin can lead to depression)

of miRNA is expressed in the brain. They target

genes at a time, which helps explain complex disease models. It also fits into modern 'pathway' method of thinking. It can also be impacted by

and envrionmental stimuli, and has shown significance with

, in particular it was further found to be associated with a gene variant called

. This is known as a high risk

, and this particular one is based on early onset of alzheimers.

. Diagnostic applications include

tesing; allowing for assessment of DNA variations assoicated with psychiatric disroders., and circulating miRNA.

applications include gene therapy; which involves

over expressed miRNA's, and

treatment in the form of deliver of synthetic miRNA mimics or sponges

is examined, and requires many

. One PRO is that this technique is

-free, and has way more

. some limitations include the issue of

testing, as well as population

and array sensitivity, but these can both be controlled for

risk score, whilst PRS stands for

risk score. There are two types of GRS;

GRS, which is the sum of risk

, and

weighted

GRS, which is as above multiplied by effect size. Both of these are restricted by genome-wide significant SNPS. This can be controlled howeverby PRS-

PRS is essentially WGRS, but unrestricted by genome-wide significant SNP

. it is suspected that

is the sector causing this. it is highly varibale in both individuals and in its own

. During the pruning stage of brain maturation, this little guy tags

responsible for pruning by depositing its sister protein

the more active this is, the more synapses are pruned, and the more likely a runaway synaptic may occur during adolescene.

was a scholar, (cousin to Charles Darwin), who applied

principles to psychology. He is famous for designing the first human

study. His study focus on familial success and

. He found that family background had a massive effect on success. He then went on to coin the term

, but he was not the first to express the concept. He was very pro

breeding though.

. the concept name was coined by

component, (due to eugenic movement by nazis). The Idea was left unchallenged for a long period of time

Money observed a set of twins, both born male, one raised as completely as female from birth after circumsision accident.

It was believed at the time that it was possible to raise a child as the other gender, without them knowing. Money's criteria for this ethical study was that the the child must not be told of its

. The entire experiment had to be kept