Peerwise immunology

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Question 1 of 1

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Which of the following is not derived from the common myeloid progenitor?

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Explanation

NK cells are from common lymphoid progenitor

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X-linked ectodermal dysplasia with immunodeficiency is caused by a defect in which of the following?

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Explanation

FOXP3 - Immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX), AIRE - Autoimmune polyendocrine syndrome type 1 (APS-1)/autoimmune polyendocrinopathy-candidiasis–ectodermal dystrophy/dysplasia (APECED), Perforin is responsible for pore formation, CD40 is a co-stimulatory protein on APCs that activatest them

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What is the general function of the TH1 response?

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Explanation

TH17 attracts neutrophils, TH2 augments antibody production, T-regs downregulate T cells, IL-1 induces fever

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On which cell would you not find MHCII?

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Explanation

Macrophages dendritic cells and B cells are APCs so express MHCII to cells. Thymic epithelial cells express MHCII to induce central tolerance. MHCII expression is not ubiquitous like MHCI

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Which of the following is incorrect

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Explanation

Farmers Lung: HRCT Thorax may show pulmonary fibrosis. Spirometry shows a restrictive pattern.

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Which of the following is correct?

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Explanation

Autoimmune Regulator (AIRE) allows the thymus to express a variety of peripheral tissue antigens, Central tolerance – Elimination of newly formed strongly autoreactive lymphocytes in the thymus Sympathetic ophthalmia – occurs after damage to eye Co-stimulatory molecules are usually upregulated by cytokines produced during inflammation.

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Which of the following is correct about Autoimmune Haemolytic Anaemia (AIHA)?

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Explanation

Direct Coomb’s test - used to test for AIHA. It detects antibodies or complement proteins that are bound to the surface of red blood cells. Also called the direct antiglobulin test (DAT), If autoantibody is IgG, it will coat the RBC. Complement mediated destruction = intravascular haemolysis There are 2 mechanisms. ONLY IF autoantibody is IgM, immune complexes are formed and complement is activated. The RBCs are lysed by MAC formation. Evidence of RBC formation: Reticulocytes on blood film

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Which of the following is NOT related to Type 2 hypersensitivity autoimmune diseases?

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Explanation

Systemic lupus erythematosus is a type 3 autoimmune disease characterised by antibody response to nucelear and cytoplasmic antigens and formation of immune complexes which deposit in tissues

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A white blood cell with high affinity IgE receptors, counterpart of mast cells but with unknown definitive function. Which cell is this?

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A 40 year old woman comes into your clinic after a referral by her GP. She has a history of weight loss, diarrhoea, tachycardia and tremor. Your findings upon examination consist of: pretibial myxoedema, exopthalmus and lid lag. After completing some more investigations in order to confirm it, what diagnosis do you reach?

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Explanation

SLE is the deposition of immune complexes in small blood vessels, joints and other organs. Clinical features include arthritis, pleurisy, anaemia and photosensitivity Goodpasture's syndrome is a Type II hypersensitivity whereby antiglomerular basement membrane antibodies attack the kidneys and other organs. Signs and symptoms include malaise, weight loss, aches and pains, haematuria. MS is an autoimmune response against Schwann cells leading to a loss of myelin sheaths. Causes tingling, numbness, pins and needles and muscle stiffness/weakness Myasthenia gravis is a loss of acetylcholine receptors at neuromuscular junctions, resulting in muscle weakness, often of eye muscles and eye lids. Get worsening double vision throughout the day. However, whilst you probably would see a lid lag, you won't see the other symptoms.

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Which of the following areas is not described as being "immunologically privileged"?

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Explanation

It is the uterus (and placenta) that are immunologically privileged not the vagina.

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Which of the statements regarding somatic hypermutation is correct?

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Explanation

Only B cells but is influenced by signals from T cells, Increases B cell receptor diversity, Mutation within the variable region

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Which hypersensitivity type is mediated by TH1, TH2 and CTL cells?

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Explanation

Type I, II and II are all mediatd by immunoglobulins, only type IV is T cell driven

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Which of the following is not mediated by antibodies?

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Graft rejection can be a problem for those patients who have just received a transplant, but which of the following statements best describes the process of chronic rejection?

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Explanation

T cell mediated response - rejection occurs after approximately 10 days where cells are primed when transplant first takes place but takes a while for naive cells to be activated is acute rejection, Donor T cells are activated by host cell APC which leads to proliferation of CTLs and NK cells which attack the host is graft versus host disease

Peerwise immunology

Question 1 of 1

Time Left

Which of the following is not derived from the common myeloid progenitor?

Select the correct answer(s).

(0/0)

Explanation

X-linked ectodermal dysplasia with immunodeficiency is caused by a defect in which of the following?

Select the correct answer(s).

(0/0)

Explanation

What is the general function of the TH1 response?

Select the correct answer(s).

(0/0)

Explanation

On which cell would you not find MHCII?

Select the correct answer(s).

(0/0)

Explanation

Which of the following is incorrect

Select the correct answer(s).

(0/0)

Explanation

Which of the following is correct?

Select the correct answer(s).

(0/0)

Explanation

Which of the following is correct about Autoimmune Haemolytic Anaemia (AIHA)?

Select the correct answer(s).

(0/0)

Explanation

Which of the following is NOT related to Type 2 hypersensitivity autoimmune diseases?

Select the correct answer(s).

(0/0)

Explanation

A white blood cell with high affinity IgE receptors, counterpart of mast cells but with unknown definitive function. Which cell is this?

Select the correct answer(s).

(0/0)

Select the correct answer(s).

(0/0)

Explanation

Which of the following areas is not described as being "immunologically privileged"?

Select the correct answer(s).

(0/0)

Explanation

Which of the statements regarding somatic hypermutation is correct?

Select the correct answer(s).

(0/0)

Explanation

Which hypersensitivity type is mediated by TH1, TH2 and CTL cells?

Select the correct answer(s).

(0/0)

Explanation

Which of the following is not mediated by antibodies?

Select the correct answer(s).

(0/0)

Graft rejection can be a problem for those patients who have just received a transplant, but which of the following statements best describes the process of chronic rejection?

Select the correct answer(s).

(0/0)

Explanation

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