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block

Which of the following is not a factor that controls normal cell proliferation

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.6 Describe the normal cell cycle and factors which control normal cell proliferation

---

Cytokine production

Contact inhibition

Anchorage to basement membrane

Growth factor secretion

Cell cycle checkpoints (tumour suppressor genes)

Cohesion to neighbours

none

With regard to bacteria sharing genetic information, match up the methods below

Match the text (click and drag)   

(0/0)

Check Order Of Answers

Explanation

CSIM 1.43 Explain the principles of development of microbial antibiotic resistance and its transmission

---

Match the text
Transformation
Transduction
Conjugation

Click and drag
Uptake of naked DNA from the environment and incorporation into a hertiable form.
Transfer of DNA via a bacteriophage.
Direct exchange: two bacteria pulled together by sex pili, relaxosome joins the two, plasmids are copied and exchanged.

Check Order of Answers

none

You are in an oncology clinic and the consultant informs you that the next patient is an African-American woman with a 'triple negative' tumour. He asks you what gene has mutated in her case. What do you say?

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.7 Describe the clinical features, main types and routes of spread of breast cancer

---

BRCA1

P53

Rb

HER2

BRCA2

none

You are on paediatric rotation and are examining a 6 month old child who has a respiratory infection. The consultant informs you that this is likely to be bronchiolitis and asks you which virus has most likely caused this. What do you answer?

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.72 List the common viral causes of respiratory tract infections together with their principle features and methods of diagnosis

---

Coronavirus

Adenovirus

Cytomegalovirus

Paramyxovirus

Rhinovirus

none

Which of the below is not a consequence of release of histamine?

Select the correct answer(s).  

(0/0)

---

Bronchodilation and asthma like symptoms

release of inflammatory cytokines and eicosanoids (family of compounds including prostaglandins – basically local hormones)

increased expression of endothelial adhesion molecules

Allergic Rhinitis, Anaphylaxis (Type 1 hypersensitivity reactions), atopic dermatitis, bronchoconstriction and asthma

activation of the pro-inflammatory transcription factor NFKB

none

Which of the following is not a treatment that would be considered in Parkinsons Disease?

Select the correct answer(s).  

(0/0)

Explanation

CPTP 3.20

---

Carbidopa (peripheral carboxylase inhibitor)

L-Dopa

Dopamine agonists

SSRIs

MOA-B inhibitors

none

How many women will develop breast cancer in their lifetime?

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.7 Describe the risk factors for breast cancer and its epidemiology

---

1 in 7

1 in 5

1 in 3

1 in 11

1 in 9

none

Regarding Hepatitis D, select the untrue statement from the list below

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.51 Describe the epidemiology, pathogenesis, morphological features and clinical course of the major hepatitides (plural hepatitis)

---

Has an outer coat of 3 proteins

No vaccine can prevent it

Incubation period 3-7 weeks

Small, spherical single-stranded circular RNA virus

Can only exist as part of a co-infection with Hepatitis B

none

What 3 things do we need to consider when assessing the GRADE of a cancer?

Select the correct answer(s).  

(0/0)

---

Blood supply

Mitotic activity

Nuclear size and pleomorphism

Type of tumour

Degree of differentiation

none

You are speaking to a patient in a breast clinic and inform her that she has Atypical Ductal Hyperplasia. She asks you to explain a little more about what this means. Which of the below statements would you NOT tell her?

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.7 Describe benign breast disease and malignant tumours and understand the techniques used to make this distinction

---

ADH incurs no increased risk of developing breast cancer

ADH incurs an increased risk of developing breast cancer

ADH is not a cancer but is pre-cancerous

none

What is the most common type of breast cancer?

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.7 Describe the clinical features, main types and routes of spread of breast cancer

---

Mucinous

Medullary

Infiltrating ductal of no special type (NST)

Tubular

Infiltrating lobular

none

Which of the following scenarios does not require reporting to Public Health England under the CoSurv system?

Select the correct answer(s).  

(0/0)

Explanation

Wrong one made up - all the others are true

---

A notifable disease is diagnosed

An organism cause haemorrhagic fever is identified

A potentially fatal case of any disease occurring in a person under the age of 30

An organism causing meningitis or encephalitis is identified

An asymptomatic case of legionella in a patient with HIV

A clinically significant bacteria is isolated in CSF/fluids extracted from the patient

none

Regarding influenza virus, select the untrue statement from the list below

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.72. Describe the clinical features, treatment and prevention of influenza virus infections. **10 types of Neuraminidase surface protein!!**

---

12 types of Neuraminidase (N) surface protein, determining strain.

An enveloped, single strand RNA virus

17 types of Haemagluttinin (H) surface protein, determining strain.

Matrix protein forms shell

Genome comprised of 8 RNA segments, linked by NP-proteins

none

Which of the following is not one of the 5 moments of hand hygiene?

Select the correct answer(s).  

(0/0)

---

Before clean/aseptic procedure

After touching a patient surroundings

After bodily fluid exposure risk

Before touching a patient

After touching a patient

After contact with patients relatives/next of kin

none

Regarding Hepatitis E, which of the below facts is untrue?

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.51 Describe the epidemiology, pathogenesis, morphological features and clinical course of the major hepatitides (plural hepatitis). **There is a vaccine on trial in China**

---

High mortality in pregnant women (30%)

Can be acquired from undercooked sausages & other pork products

Vaccine widely available in UK

Self-limiting unless host is immunocompromised

Positive-sense single-stranded non-enveloped RNA icosahedral virus