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block

Select two side effects that can occur as a result of using monoamineoxidase inhibitors

Select the correct answer(s).  

(0/0)

Explanation

If you are switching drugs: MOAI to Fluoxetine needs a gap of 2 weeks. Fluoxetine to MAOI needs a gap of 5 weeks

---

Hypertensive crisis if patient eats lots of cheese

Hyperthyroidism

Hypercalcaemia

Serotonin Syndrome

Cushings Syndrome

none

Which of the following is not a known pathophysiological cause of oesophagitis?

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.50. Describe the pathogenesis etc of Oesophagitis, Gastritis and Peptic Ulcer Disease. Tough question! But TB can cause it. UC is restricted to the lower bowel so will not cause oesophagitis.

---

Defective lower oesophgal sphincter

Crohn's Disease

Ulcerative Colitis

Tuberculosis

Gastric surgery

Barratt's Oesophagus

none

Which of the following conditions has no association with neoplasia/cancer

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.49 Describe the main features of chronic inflammation.

---

Marjolins Ulcer

Angina Pectoris

Barratts Oesophagus

Crohns Disease

Ulcerative Colitis

none

With regard to adaptive immunity, select the true statement from the list below

Select the correct answer(s).  

(0/0)

Explanation

MHC II must act with co-receptor CD4. If it was recognised by all cells, cytotoxic cells would end up killing all sorts of random cells but they need to be kept to killing cells with intracellular infections (MHC I/CD8)

---

Dendritic cells express MHC I and MHC II so they can activate both types of T-cell

T-cells will either express CD4 or CD8 but never both

The antigens held in MHC II molecules can be ubiquitously recognised by any cell with an appropriate receptor

The antigens held in MHC I can only be recognised if the approaching cell expresses co-receptor CD8

none

Newer monoamineoxidase inhibitors such as Moclopemide have a specific mechanism of action. What is it?

Select the correct answer(s).  

(0/0)

Explanation

Older ones irreversibly and selectively inhibit MOA-A and MOA-B

---

Irreversibly and selectively inhibit MOA-A and MOA-B

Non selective inhibition of all presynaptic enzymes

Irreversibly and selectively inhibit MOA-A

Reversibly and selectively inhibit MOA-A

Reversibly and selectively inhibit MOA-A and MOA-B

none

Match up the MHC molecules with their features

Match the text (click and drag)   

(0/0)

Check Order Of Answers

Explanation

This makes sense. CD8 cytotoxic cells only like MHC I (intracellular pathogens). As the role of CD8 cells is to kill virus infected cells, MHC I is perfect for them!

---

Match the text
MHC I
MHC II

Click and drag
Extracellular pathogens
Intracellular pathogens

Check Order of Answers

none

Match the chemotherapies and their mechanisms of action

Match the text (click and drag)   

(0/0)

Check Order Of Answers

---

Match the text
Cycloposphomide
Doxorubicin
Methotrexate
Vincristine
Imatinib
Tamoxifen

Click and drag
Topioisomerase II inhibitor: prevents unwinding of DNA helix
Spindle toxin: inhibits the microtubules that pull chromosomes apart during mitosis
Forms crude cross link on DNA, blocking synthesis
Blocks oestrogen receptor on hormone-dependent breast cancers
Tyrosine kinase inhibitor: blocks ATP binding site, preventing cell proliferation on BCR-ABL cancers
Folate synthesis inhibitor: stops folate and amino acids being produced. Administered in lethal dose then reversed with folinic acid 24 hours later

Check Order of Answers

none

Examine the table below. Which of these diseases is Crohns Disease?

Select the correct answer(s).  

(0/0)

---

A

B

Neither

none

Select the least specific and most crude chemotherapeutic agent from the list below

Select the correct answer(s).  

(0/0)

---

Cyclophosphamide

Vincristine

Imatinib

Doxorubicin

Tamoxifen

none

A dendritic cell living in the skin and tissue is also called what?

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.12. Describe the major cells involved in the immune response

---

Cutaneocyte

Distal APC

Langerhans Cell

APC-cell

Tissue Dendritic Cell

none

In a neoplasm (tumour), the fraction of cells remaining in the proliferative pool is known as what?

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.6 Describe the normal cell cycle and factors which control normal cell proliferation

---

Neoplastic number

Tumour fraction

Mitotic fraction

Carcinogenetic fraction

Growth fraction

none

Generally, if a patient had a serious helminth (worm) infection, what specific cell would you expect to see in high numbers in blood results?

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.12. Describe the major cells involved in the immune response

---

Mast Cells

Neutrophils

Eosinphils

Basophils

Macrophages

none

I am a tumor suppressor protein that is dysfunctional in several major cancers. One of my functions is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, I am phosphorylated and become inactive and allows cell cycle progression. Once the cell has divided I am then dephosphorylated again to inhibit cell division and allow cell growth (G1 phase of the cell cycle). What is my name?

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.6 Describe the normal cell cycle and factors which control normal cell proliferation

---

TNF-a gene

Rb gene

HLAB 27 gene

G1 gene

TNF-B gene

none

Order the basic outline of the adaptive immune response below

Match the text (click and drag)   

(0/0)

Check Order Of Answers

---

Match the Text
1
2
3
4

Click and drag
A minute proportion of T-cells recogise the antigen and are activated = mature T-cells. They turn into 'Effector T-Cells'
In the lymph nodes, the Dendritic Cells present the antigen to millions of passing naive T-cells. The vast majority of these T-cells will not recognise the pathogenic antigen
Effector T-cells go on to activate B-cells to produce antibodies against the pathogenic antigen
Dendritic Cells encounter an antigen and transport it to the lymph nodes where it is 'presented'

Check Order of Answers

none

Which of the following cells is commonly accepted to be the main antigen presenting cell in the body?

Select the correct answer(s).  

(0/0)

Explanation

CSIM 1.12. Describe the major cells involved in the immune response

---

B-Cell

Basophil

Macrophage

Neutrophil

Dendritic Cell