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Question 1 of 1

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61500

120

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with competitive inhibition of an enzyme...

Select the correct answer(s).

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Explanation

increased Km means a decreased affinity of enzyme to its substrate, unchanged Vmax means the max. ROR is still the same

61502

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with non-competitive inhibition of an enzyme...

Select the correct answer(s).

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Explanation

Affinity of enzyme to substrate (Km) is unchanged but, due to fewer enzymes being active the ROR (Vmax) is decreased

61504

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Which of these amino acids is most likely to be found on the outside of globular protein?

Select the correct answer(s).

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Explanation

serene has a polar side chain, all the others have non-polar side chains

61507

120

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Which of these amino acids is non-polar

Select the correct answer(s).

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Explanation

methionine is non polar, asparagine is polar, aspartate is acidic (aka aspartic acid) (so is -ve in solution), arginine is basic (so +ve in solution)

61509

120

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which two amino acids contain sulphur

Select the correct answer(s).

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Explanation

tyrosine is an aromatic polar aa, serine is a polar aa, phenylalanine is an aromatic non-polar aa, only cysteine and methionine contain sulphur

61512

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which three amino acids are ALL non-polar

Select the correct answer(s).

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Explanation

non-polar: glycine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, tryptophan and proline. Polar: serine, threonine, cysteine, tyrosine, asparagine and glutamine Acidic (-ve): aspartate and glutamate

61513

120

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Which of these amino acids is NOT aromatic

Select the correct answer(s).

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Explanation

phenylalanine, tryptophan and tyrosine are the only 3 aromatic amino acids

61514

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which of these facts about non-steroidal anti-inflammatory drugs (NSAIDs) is FALSE

Select the correct answer(s).

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Explanation

the binding of aspirin to the COX-1 enzyme is covalent and so irreversible however ibuprofen binds reversibly to the active site of the COX-1 enzyme

61516

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Which of these statements about glucose-6-phosphate dehydrogenase deficiency are FALSE?

Select the correct answer(s).

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Explanation

haemolytic crisises (and jaundice) are triggered by certain drugs, foods (incl. fava bean, sometime called favism) or infections

61521

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which of these is NOT a serine protease inhibitor (aka serpin)?

Select the correct answer(s).

(0/0)

Explanation

ACE inhibitors block conversion of angiotensin I to angiotensin II but is NOT a serpin. a1-antitrypsin prevents protease from attacking tissue, pancreatic trypsin inhibitor controls activity of digestive enzyme, anti-thrombin III switches off blood clotti

61523

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which of these facts about serene proteases is FALSE?

Select the correct answer(s).

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Explanation

serpins are inhibitors or serine proteases

61524

120

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which of these blood clotting factors are NOT vitamin K dependent?

Select the correct answer(s).

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Explanation

factors: 7a, 10a, 9a and thrombin are all vit K dependent

61528

120

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Which of these facts about plasmin is FALSE?

Select the correct answer(s).

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Explanation

TPA is tissue-type plasminogen activator and activates plasmin from plasminogen by proteolysis. recombinant TPA (rTPA) and streptokinase are drugs which mimic TPA in order to break down fibrin clots and increase survival rates in patients who have had hea

61531

120

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The enzyme inhibitor methotrexate

Select the correct answer(s).

(0/0)

Explanation

methotrexate inhibits the action of dihydrofolate reductase, which is an enzyme involved in the biosynthesis of nucleotides. So methotrexate is used in chemotherapy as it preferentially affects rapidly dividing cells (i.e. cancer cells) however side effec

61538

120

none

which of these liver function tests are abnormal if low?

Select the correct answer(s).

(0/0)

Explanation

low albumin can indicate general loss of secretory function or kidney disease. High transaminases (GOT/GPT) could indicate liver necrosis, paracetamol poisoning and others. High alkaline phosphotase (ALP) could indicate large bile duct obstruction (but ca

IMS revision

Question 1 of 1

Time Left

with competitive inhibition of an enzyme...

Select the correct answer(s).

(0/0)

Explanation

with non-competitive inhibition of an enzyme...

Select the correct answer(s).

(0/0)

Explanation

Which of these amino acids is most likely to be found on the outside of globular protein?

Select the correct answer(s).

(0/0)

Explanation

Which of these amino acids is non-polar

Select the correct answer(s).

(0/0)

Explanation

which two amino acids contain sulphur

Select the correct answer(s).

(0/0)

Explanation

which three amino acids are ALL non-polar

Select the correct answer(s).

(0/0)

Explanation

Which of these amino acids is NOT aromatic

Select the correct answer(s).

(0/0)

Explanation

which of these facts about non-steroidal anti-inflammatory drugs (NSAIDs) is FALSE

Select the correct answer(s).

(0/0)

Explanation

Which of these statements about glucose-6-phosphate dehydrogenase deficiency are FALSE?

Select the correct answer(s).

(0/0)

Explanation

which of these is NOT a serine protease inhibitor (aka serpin)?

Select the correct answer(s).

(0/0)

Explanation

which of these facts about serene proteases is FALSE?

Select the correct answer(s).

(0/0)

Explanation

which of these blood clotting factors are NOT vitamin K dependent?

Select the correct answer(s).

(0/0)

Explanation

Which of these facts about plasmin is FALSE?

Select the correct answer(s).

(0/0)

Explanation

The enzyme inhibitor methotrexate

Select the correct answer(s).

(0/0)

Explanation

which of these liver function tests are abnormal if low?

Select the correct answer(s).

(0/0)

Explanation

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