5HT3 and 5HT4

5HT1A and 5HT1D

5HTX and 5HT2C

5HTY and 5HTZ

5HT1A and 5HT2A

Heroin addicts can usual tolerate high doses, but are not tolerant on the occasion of the overdose

Victims of heroin overdose are typically not novice users, but rather addicts with high levels of tolerance

An unexpectedly high dose will not lead to the usual conditioned response

An unexpectedly low dose will not lead to the usual conditioned response

A disproportianate number of heroin overdoses take place in unfamiliar settings

The effectiveness of a drug when only 50% of the required dose is administered

The time after the expiry date of the drug where it is only 50% as effective

The time required for the body to eliminate 50% of the drug

The time a drug takes to wear off when only 50% of the required dose is administered

When only 50% of the expected effects of the drug are observed

The absorption, distribution, metabolism and excretion of drugs

The prevention of drug molecules from entering surrounding tissue

How and where a drug is administered to the body

Measuring the time-dependent plasma concentrations of a drug

The group of general body capillaries that allow drug molecules to pass through tissue

Methylenedioxymethamphetamine (MDMA)

A tryptophan rich diet

Stereotaxic lesions of the globus pallidus

Selective serotonin re-uptake inhibitors

Benzodiazepines

Histomine, dopmaine and norepinephrine

Serotonin, dopamine and norepinephrine

Serotonin, dopamine and noradrenaline

Serotonin, histomine and noradrenaline

Serotonin, histomine and norepinephrine

Tofranil

Melipramine

Iproniazid

Imipramine

Amitriptyline

30%

50%

70%

90%

10%

Repeated measures are taken by pre and post-dose testing

There is a wash out period between periods 1 and 2

A snowball sampling technique is used

Only the drug main effects are recorded

The placebo and active treatment groups are counterbalanced so that both groups are involved simultaneously