GNRS 582B Exam 1 Prep

Question 1 of 1

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GNRS 582B Exam 1 Prep

Question 1 of 1

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10. The Philadelphia chromosome, a genetic translocation between chromosomes 9 and 22, is most frequently observed (95%) in those with ____CML___. Its presence carries a poor prognosis.

Hemophilia A is a factor VIII deficiency that interrupts the clotting cascade. It is a hereditary disease that causes life threatening bleeding.

Hemoglobin S (Hb S) is formed by a genetic mutation in which ___valine______ replaces ______glutamic acid_______.

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Anaplasia – loss of cellular differentiation

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Loss of heterozygosity can unmask inactivating mutations in recessive tumor-suppressor genes

“Up to one-third of all cancers have an activating mutation in the gene for an intracellular protein called RAS. This mutant RAS stimulates cell growth even when external growth factors are absent.” (p. 235)

Most common cancers among men - Lung, prostate, colon, stomach, and liver Most common cancers among women – breast, colon, lung, cervix, and stomach

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Thrombocytopenia Platelet count <100,000/mm3

Megaloblastic Anemia – Pernicious Anemia

10. The Philadelphia chromosome, a genetic translocation between chromosomes 9 and 22, is most frequently observed (95%) in those with __CML_. Its presence carries a poor prognosis.

Hemoglobin S (Hb S) is formed by a genetic mutation in which _valine replaces glutamic acid_____.