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block

Which of the following reactions does not use ATP as a substrate in the glycolysis pathway?

Select the correct answer(s).  

(0/0)

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Phosphofructokinase

Pyruvate kinase

Adenylate kinase

Hexokinase

Glucokinase

none

Characteristics of succinate dehydrogenase include all EXCEPT:

Select the correct answer(s).  

(0/0)

---

removes hydrogens from C-O bonds.

carries out either 1-electron or 2-electron transfers to/from FAD.

is a membrane-bound enzyme.

has covalently bound FAD.

also known as succinate-Coenzyme Q reductase.

none

The _______ of pyruvate to acetyl-CoA is catalyzed by ______.

Select the correct answer(s).  

(0/0)

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b. oxidative decarboxylations; pyruvate dehydrogenase complex

c. decarboxylations; pyruvate decarboxylase

e. none of the above.

d. transacylation; pyruvate transacylase

a. dehydration; pyruvate dehydration complex

none

Fluoroacetate inhibits the TCA cycle. Although it does not inhibit citrate synthase, the product inhibits:

Select the correct answer(s).  

(0/0)

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isocitrate dehydrogenase.

succinate dehydrogenase.

aconitase.

pyruvate dehydrogenase.

α-ketoglutarate dehydrogenase.

none

Citrate must be isomerized to isocitrate because the ______ group of citrate is not oxidizable, but the ____ group of isocitrate can be oxidized.

Select the correct answer(s).  

(0/0)

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ketone; secondary alcohol

tertiary alcohol; secondary alcohol

secondary alcohol; ketone

ketone; primary alcohol

aldehyde; primary alcohol

none

The modest oxidation that occurs in glycolysis involves the removal of _____ electrons, total, from glucose to pyruvate.

Select the correct answer(s).  

(0/0)

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5

2

3

4

1

none

What is the purpose of phosphorylating glucose in cytosol?

Select the correct answer(s).  

(0/0)

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a) To trap glucose in the cell

c) To convert it to a more soluble form

e) a and b

b) To destabilize glucose and facilitate the next series of metabolic steps

d) All of the above

none

. The electrons removed from glucose via NADH formation are used to

Select the correct answer(s).  

(0/0)

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make ATP in mitochondria under anaerobic conditions.

form 3-phosphoglycerate

reduce pyruvate to lactate, regenerating NAD+

form ethanol in the liver

none

The correct sequence of steps between succinyl-CoA and ATP in mammals to “preserve” the energy of the thioester bond are: A) succinyl-phosphate. B) phosphohistidine. C) GTP. D) Acetyl-CoA.

Select the correct answer(s).  

(0/0)

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A, B, C

D, A, B

C, B, D

A, C, D

B, C, D

none

In the TCA cycle, carbon enters the cycle as __ and exits as ___ with metabolic energy captured as _______, ____ and ______.

Select the correct answer(s).  

(0/0)

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b. acetyl-CoA; CO2; NADH; ATP; NADPH

c. succinyl-CoA; CO2; ATP; NADH; NADPH

d. acetyl-CoA; CO2; ATP; NADH; [FADH2]

e. malonyl-CoA; water; NADH; [FADH2]; ATP

a. malonate; water; NADH; ATP; NADPH

none

Citrate synthase has a ________ΔGo’ and is essentially __________ even though the mitochondrial concentration of ________ is very low.

Select the correct answer(s).  

(0/0)

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d. large negative; irreversible; OAA

c. nearly zero; irreversible; OAA

a. large positive; reversible; acetyl-CoA

b. nearly zero; reversible; OAA

e. large negative; reversible; acetyl-CoA

none

In eukaryotic cells, glycolysis occurs in the ______, and the TCA cycle reactions take place in _____.

Select the correct answer(s).  

(0/0)

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a. mitochondria; mitochondria

b. cytoplasm; mitochondria

e. cytoplasm; ribosomes

d. mitochondria; ribosomes

c. cytoplasm; cytoplasm

none

Allosteric inhibitors of isocitrate dehydrogenase include _____ and ____, whereas ____ acts as an allosteric activator, _____ the Km for isocitrate.

Select the correct answer(s).  

(0/0)

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e. NADH; ATP; AMP; lowering

d. NADH; ATP; ADP; increasing

b. ATP; ADP; AMP; lowering

a. ATP; NADH; ADP; lowering

c. NADH; NADPH; AMP; increasing

none

The only reaction of the citric acid cycle that provides substrate-level phosphorylation is catalyzed by:

Select the correct answer(s).  

(0/0)

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citrate synthase.

malate dehydrogenase.

nucleotide triphosphate kinase.

succinyl-CoA synthetase.

isocitrate dehydrogenase.

none

The two step reaction catalyzed by isocitrate dehydrogenase involves: A. β-decarboxylation expelling the α-keto carboxyl as CO2. B. oxidation of the C-2 alcohol of isocitrate to form oxalosuccinate. C. oxidation of the C-2 alcohol to form oxaloacetate. D. β-elimination expelling the central carboxyl group as CO2.

Select the correct answer(s).  

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B and D

B and C

A and B

A and C

C and D