Endothelial Function/Disfunction

endothelial-function-disfunction

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Question 1 of 1

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589604

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Which type of muscarinic receptor does acetylcholine bind to on the endothelium?

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Explanation

Acetylcholine binds to M3 muscarinic G protein coupled receptors. This activates phospholipase C, which produces Inositol triphosphate, causing release of calcium from the sarcoplasmic reticulum.

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Elevation in plasma cholesterol levels is associated with ...

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Explanation

Elevation in plasma cholesterol levels at any age are associated with impaired endothelium-dependent vasodilation.

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Which is the stable metabolite of prostacyclin (PGI₂) released from endothelial cells on ACh stimulation?

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Explanation

This form part of the evidence that for some arterial vessels, PGI₂ is an ERDF.

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Which enzyme converts membrane phospholipids into arachidonic acid?

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Large conductance calcium dependent potassium channels are selectively blocked by ...

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PGI₂ (Prostacyclin) ...

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Explanation

Prostacyclin has little/no contribution to resting levels of arterial blood pressure (via TPR). If it had a contribution to ABP, it would reduce resting levels of ABP via decreasing total peripheral resistance. This is because prostacyclin is a vasodilator. In other words, prostacyclin has little/no contribution to vasodilator tone in tissues. Prostacyclin partly accounts for vasodilator responses to increased sheer stress, and it partly accounts for the vasodilator response to hypoxia. Note that the removal of endothelium has bigger effects in reducing the vasodilator effect than COX inhibition.

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What is a synthetic analogue of prostacyclin PGI2?

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Explanation

For some arterial vessels, iloprost evokes relaxation.

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Which enzyme degrades natriuretic peptides?

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Explanation

Neutral endopeptidase (NEP) is a circulating enzymes that degrades natriuretic peptides.

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NO diffuses into smooth muscle cells and activates ...

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Explanation

NO produced in endothelial cells diffuses into vascular smooth muscle cells to dephosphorylate GTP to cGMP. Cyclic GMP causes smooth muscle relaxation via various functions.

Endothelial Function/Disfunction

Question 1 of 1

Time Left

Which type of muscarinic receptor does acetylcholine bind to on the endothelium?

Select the correct answer(s).

(0/0)

Explanation

Elevation in plasma cholesterol levels is associated with ...

Select the correct answer(s).

(0/0)

Explanation

Which is the stable metabolite of prostacyclin (PGI₂) released from endothelial cells on ACh stimulation?

Select the correct answer(s).

(0/0)

Explanation

Which enzyme converts membrane phospholipids into arachidonic acid?

Select the correct answer(s).

(0/0)

Large conductance calcium dependent potassium channels are selectively blocked by ...

Select the correct answer(s).

(0/0)

PGI₂ (Prostacyclin) ...

Select the correct answer(s).

(0/0)

Explanation

What is a synthetic analogue of prostacyclin PGI2?

Select the correct answer(s).

(0/0)

Explanation

Which enzyme degrades natriuretic peptides?

Select the correct answer(s).

(0/0)

Explanation

NO diffuses into smooth muscle cells and activates ...

Select the correct answer(s).

(0/0)

Explanation

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