Drugs

Question 1 of 1

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Match the drugs to their targets:

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B-lactam
Quinalones
Glycopeptides
Aminoglycosides
Tetracyclins
Macrolides
Rifampicin
Folate inhibitors
Membrane disrupting protein

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Target: Bacterial cell wall synthesis (Gram +)
Target: 30s prevent amino acid incorperation
Target: Topoisomerases in the bacterial cell (TOPO I & DNA gyrase) that prevent supercoiling. This prevents bacterial replication.
Target: Membrane structure, protiens get between the phospholipids and break up the membrane. Found in some disinfectants but rarely used due to the lack of specificity.
Target: Inhibits RNA polymerase, usually used in combination with other drugs.
Target: amino acid creation in bacteria. Target the molecular pathways for folate creation specific to bacteria.
Target: 30s ribosomal subunit, prevent initiation of protein synthesis. Can be damaging to renal system and hearing at high doses.
Target: 50s prevent polypeptide translocation.
Target: cell wall synthesis- Binds to transpeptidases involved in cross linking, resulting in the collapse of the cell wall