Drugs

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Match the drugs to their targets:

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B-lactam

Quinalones

Glycopeptides

Aminoglycosides

Tetracyclins

Macrolides

Rifampicin

Folate inhibitors

Membrane disrupting protein

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Target: 50s prevent polypeptide translocation.

Target: Topoisomerases in the bacterial cell (TOPO I & DNA gyrase) that prevent supercoiling. This prevents bacterial replication.

Target: amino acid creation in bacteria. Target the molecular pathways for folate creation specific to bacteria.

Target: Membrane structure, protiens get between the phospholipids and break up the membrane. Found in some disinfectants but rarely used due to the lack of specificity.

Target: Bacterial cell wall synthesis (Gram +)

Target: cell wall synthesis- Binds to transpeptidases involved in cross linking, resulting in the collapse of the cell wall

Target: 30s prevent amino acid incorperation

Target: Inhibits RNA polymerase, usually used in combination with other drugs.

Target: 30s ribosomal subunit, prevent initiation of protein synthesis. Can be damaging to renal system and hearing at high doses.


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