fibrosarcoma.

leiomyosarcoma.

rhabdomyosarcoma.

gastrointestinal stromal tumor.

liposarcoma.

White women

African-American men

Asian women

White men

African-American women

Uncontrolled hypertension

Lower extremity edema

Hematuria

Neurologic symptoms

Abdominal pain and palpable mass

Tumor size

Histologic subtype and tumor grade

Complete surgical resection with negative margins

Patient age

Administration of neoadjuvant chemotherapy

Adrenal gland

Colon

Spleen

Distal pancreas

Kidney

10%

5%

0.2

40%

More than 50%

Imatinib

Doxorubicin

Cisplatin

Methotrexate/vinblastine/doxorubicin/cisplatin

Bleomycin/etoposide/platinum

Retroperitoneal sarcomas are slightly more common in men.

Retroperitoneal sarcomas comprise less than half of all tumors presenting in the retroperitoneum.

The most common age at presentation for a retroperitoneal sarcoma is in the sixth decade.

The incidence of retroperitoneal sarcoma has been rising steadily over the past 30 years.

Retroperitoneal sarcomas account for 15% of all soft tissue sarcomas.

Rhabdomyosarcoma

Liposarcoma

Fibrosarcoma

Leiomyosarcoma

Malignant fibrous histiocytoma

The peak incidence of retroperitoneal sarcoma is in the third decade.

The average 5-year survival for completely resected retroperitoneal sarcoma is approximately 50%.

All patients require computed tomographic–guided biopsy before surgical resection.

The risk of local recurrence after resection of a retroperitoneal sarcoma is very low.

Neoadjuvant chemotherapy is the standard of care for retroperitoneal sarcoma.