DNA MCQ - Cellular Response to DNA Damage

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0 [{"id":130305,"quiz_id":"8687","answer_id":null,"answerType_id":"1","created_at":"2016-11-26 20:09:44","updated_at":"2016-11-27 12:29:31","questionName":"Fill in the blanks","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":4,"explanation":"","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130304,"quiz_id":"8687","answer_id":null,"answerType_id":"0","created_at":"2016-11-26 20:05:52","updated_at":"2016-11-27 12:29:31","questionName":"Which direct repair enzyme is found in B. subtilis?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":3,"explanation":"","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130311,"quiz_id":"8687","answer_id":null,"answerType_id":"0","created_at":"2016-11-26 20:37:40","updated_at":"2016-11-27 12:29:31","questionName":"Recognition of DNA damage in Nucleotide Excision Repair involves which protein?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":10,"explanation":"\uf076\tXPC protein (originally called C and found in Xeroderma pigmentosum patients) stably binds to another protein called HHRAD23B. ","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130301,"quiz_id":"8687","answer_id":null,"answerType_id":"0","created_at":"2016-11-26 19:54:37","updated_at":"2016-11-27 12:29:31","questionName":"Reversal of base damage (direct repair) is carried out via what method?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":0,"explanation":"Using DNA photolyase, direct repair of DNA damage can be carried out by photoreactivation of the DNA.","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130308,"quiz_id":"8687","answer_id":null,"answerType_id":"0","created_at":"2016-11-26 20:30:36","updated_at":"2016-11-27 12:29:31","questionName":"Which of these are believed to be involved in MMR?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":7,"explanation":"MMR defects lead to cancer (mainly colon, uterine, ovarian, gastric)","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130316,"quiz_id":"8687","answer_id":null,"answerType_id":"0","created_at":"2016-11-26 20:58:05","updated_at":"2016-11-27 12:29:31","questionName":"Which protein makes a 5' incision ~24-25 nucleotides from the damage site in nucleotide excision repair?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":14,"explanation":"","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130307,"quiz_id":"8687","answer_id":null,"answerType_id":"0","created_at":"2016-11-26 20:28:56","updated_at":"2016-11-27 12:29:31","questionName":"In humans, mismatch excision repair occurs once recognition of small loops generated by nucleotide indels and single base mismatches is accomplished. What protein is involved in this?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":6,"explanation":"MUTS\u03b1 is a heterodimer of MSH2 and MSH6. Another heterodimer (MUTS\u03b2) comprising of MSH2 and MSH3 also recognises small loops in MMR.","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130313,"quiz_id":"8687","answer_id":null,"answerType_id":"1","created_at":"2016-11-26 20:47:43","updated_at":"2016-11-27 12:29:31","questionName":"Fill in the Blanks","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":12,"explanation":"Following this ERCC1 and XPF bind to the complex and generate the complete assembly of the NE repairosome","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130302,"quiz_id":"8687","answer_id":null,"answerType_id":"0","created_at":"2016-11-26 19:56:34","updated_at":"2016-11-27 12:29:31","questionName":"Reversal of base damage (direct repair) is carried out via what method?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":1,"explanation":"Using DNA photolyase, direct repair of DNA damage caused by UV light exposure (leading to the formation of CPDs and 6-4PPs) can be carried out by photoreactivation of the DNA.","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130303,"quiz_id":"8687","answer_id":null,"answerType_id":"0","created_at":"2016-11-26 20:02:35","updated_at":"2016-11-27 12:29:31","questionName":"What direct repair enzyme is not found in E.coli, humans or yeast?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":2,"explanation":"","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130315,"quiz_id":"8687","answer_id":null,"answerType_id":"1","created_at":"2016-11-26 20:55:27","updated_at":"2016-11-27 12:29:31","questionName":"Fill in the blanks","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":13,"explanation":"","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130306,"quiz_id":"8687","answer_id":null,"answerType_id":"0","created_at":"2016-11-26 20:18:12","updated_at":"2016-11-27 12:29:31","questionName":"Mismatch excision repair involves the excision of a nucleotide that has incorrectly paired with a correct nucleotide on the opposite strand. When do these errors normally arise in cells?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":5,"explanation":"The errors normally occur in replication due to the low fidelity of the DNA replication machinery however the precise mechanism in eukaryotes is not known.","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130312,"quiz_id":"8687","answer_id":null,"answerType_id":"0","created_at":"2016-11-26 20:43:38","updated_at":"2016-11-27 12:29:31","questionName":"Formation of the XPC-HHRAD23B complex in the Recognition of Base Damage in Nucleotide Excision Repair is followed by the binding of other proteins to the sight. Of those which bind, which are specifically involved in the recognition of DNA damage?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":11,"explanation":"","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130309,"quiz_id":"8687","answer_id":null,"answerType_id":"0","created_at":"2016-11-26 20:32:13","updated_at":"2016-11-27 12:29:31","questionName":"Nucleotide Excision Repiar (NER) is the excision of how many nucleotides around the damaged DNA site?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":8,"explanation":"This method is used for solving bulky pieces of DNA damage.","question_score_id":null,"lang":null,"questionAudioPath":null},{"id":130310,"quiz_id":"8687","answer_id":null,"answerType_id":"0","created_at":"2016-11-26 20:34:01","updated_at":"2016-11-27 12:29:31","questionName":"Nucleotide Excision Repiar (NER) is the excision of how many nucleotides around the damaged DNA site?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":9,"explanation":"This method is used for solving bulky pieces of DNA damage. NER has three stages: Recognition of Base Damage, Bimodal incision and Repair Synthesis and Ligation.","question_score_id":null,"lang":null,"questionAudioPath":null}]
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O6- methylguanine DNA methyltransferase transfers

groups of O6 methylguanine and other alkyl groups to a

residue on the enzyme. This has been found in all species tested.



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