Cell Pathology

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Clinical features of acute inflammation

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Local symptoms and signs

Systemic symptoms and signs

Vascular calibre and flow increased

Adhesion molecules are expressed

Vascular permeability increased

Serous exudate

Fibrinous exudate

Purulent exudate

Histamine

Complement system

Interleukins

Prostaglandins and leukotrienes

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Affects smooth muscle in blood vessels and permeability of blood vessels

Allows inflammatory cells to stick to the vessel wall so they're more likely to go through the vessels into the tissue

Fluid

Causes redness and swelling

Malaise, loss of appetite, fever and shock

Released from basophils, mast cells and platelets. Seen in allergic response and causes vascular permeability, oedema and swelling

Contains fibrin

Causes swelling and allows exudate through (cells and mediators)

20 proteins activated in a cascade sequence, important in many diseases and its effects are chemotaxis, phagocytosis and lyse bacterial membranes

Pus, contains fibrin and inflammatory cells, debris and fluid

Many different proteins with different effects, can be pro or anti inflammatory and can be pro or anti coagulant. Induce fever, malaise and weight loss. Promote cell proliferation and collagen production

Painful and hot, swelling, erythema, heat and exudate


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