Case 2 - Kidneys

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Describe how CKD leads to hypertension and ischaemia

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In CKD, there is reduced

which causes the release of

as the kidney detects low BP so tries to correct it. The release of this results in the release of angiotensin II and

Angiotensin II causes

and aldosterone causes

reabsorption. This results in hypertension and peripheral and pulmonary

There is ischaemic damage to the medulla so the kidneys lose the ability to produce

urine.



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