Case 2 - Kidneys

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Put the steps of the pathogenesis of a UTI in order

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Replicate rapidly and immune system subversion

Most tissue damage is by bacterial toxins

Ascend the urethra

Ascend the ureter

Establish a base camp by colonising the periurethral skin - uropathogen e.g. E.coli from the gut

Epithelial damage by bacterial toxins and proteases

Colonisation of the kidneys

Biofilm formation

Adhere to the urothelium, mediated by pilli and adhesins

May cause bacteraemia

To infect the kidneys:


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