C1 - Ca Signalling in the Heart

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ECC experiments

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Match the text

Fabiato aim

Fabiato technique

Fabiato results

Nabauer aim

Nabauer technique

Nabauer results

Ferrier & Howlett aim

Ferrier & Howlett technique

Ferrier & Howlett results

Song aim

Song technique

Song results

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disruption of couplon in pathology

disruption of close apposition of RyR and LTCC in SHR myocytes

double IHC staining of LTCC and RyRs in SHR- and WT- isolated rat VMs

Demonstrate CICR = mech for ECC

veparamil --> marked attenuation of ECC

Isolated G.Pig VMs, V clamped - depolarising pulses w/\verap+w/\lidocaine

inc. EC Ca --> inc. SR Ca release

mech. skinned purkinje fibres, exposed to increasing Ca2+

without EC Ca, ECC abolished

enzymatically isolated rat VMs, WC patch, V-clamp pulses from -60-->0mV, sarcolemmal flux & Ca transients recorded, with and without EC Ca

Separate the currents involved in ECC

First to suggest CICR as mech for ECC


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