C1 - Ca Signalling in the Heart

Exit

Question 1 of 1

  Time Left


0
49220
0
600
block

ECC experiments

Match the text (click and drag)   

(0/0)




Match the text

Fabiato aim

Fabiato technique

Fabiato results

Nabauer aim

Nabauer technique

Nabauer results

Ferrier & Howlett aim

Ferrier & Howlett technique

Ferrier & Howlett results

Song aim

Song technique

Song results

Click and drag

disruption of close apposition of RyR and LTCC in SHR myocytes

disruption of couplon in pathology

inc. EC Ca --> inc. SR Ca release

Separate the currents involved in ECC

Demonstrate CICR = mech for ECC

without EC Ca, ECC abolished

Isolated G.Pig VMs, V clamped - depolarising pulses w/\verap+w/\lidocaine

First to suggest CICR as mech for ECC

mech. skinned purkinje fibres, exposed to increasing Ca2+

enzymatically isolated rat VMs, WC patch, V-clamp pulses from -60-->0mV, sarcolemmal flux & Ca transients recorded, with and without EC Ca

veparamil --> marked attenuation of ECC

double IHC staining of LTCC and RyRs in SHR- and WT- isolated rat VMs


49221
0
120
none
49222
0
600
none
49223
0
120
none
49224
0
600
none
49225
0
600
none
49226
0
120
none
49211
0
120
none