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A 45-year-old man injured his thigh when falling of electrical bicycle. Two days later he presents with severe thigh pain. The wound is opened with a foul odor and palpable subcutaneous emphysema surrounding it. The tissue around the wound seems edematous and infected. A few hours later the involved area has expanded significantly. Systolic blood pressure is 80 mm Hg. Which of the following treatments will most likely save this patient life?

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