co-administration with a vasoconstrictor strengthens the anesthetic to provide a stronger block

most effective when unionised

causes reverisble block of nerve conduction

ester linked local anaesthetics have a shorter half life than amide linked anaesthetics

prevent both generation and conduction of action potentials

co-administration with a vasoconstrictor localises the anesthetic to the desired site

target the intracellular side of NA channel

the lower the pKa the quicker the onset of action

work most effectively in inflammed tissues

most effective when a weak base

the more hydrophobic the shorter the duration of action

adding functional groups onto the aromatic ring or amino nitrogen increases the hydrophobicity

highly hydrophobic anaesthetics are the most clinically effective

do not work in inflammed tisseus

most effective when ionised

become ionised in the slightly acidic environment of neurones

the more hydrophobic the longer the duration of action

moderatly hydrophobic anaesthetics are the most clinically effective

Muscle relaxation

Suppress apetite

Suppress bleeding

Ensure muscle tone

Knock the patient uncocnious

Suppress pain - Analgeisa

General Anaesthetics that are more Water soluble are more potent

General Anaesthetics that are more lipid soluble - are more potent

General Anaesthetics that act on NA channels are more potent

General Anaesthetics that have a lower pKa are more potent

Inhaled GAs have a rapid onset as they are highly lipohpilic and can perfuse the brain and spinal cord

Inhaled GA's can accumulate in fatty tissue

Inhaled GA's are used throughout surgery as the depth of anaesthesia can be rapidly altered by altering drug concentration

Inhaled GAs with a low blood:gas coefficient produce rapid induction and recovery (NO + desflurane)

IV GAs have a rapid onset as they are highly lipohpilic and can perfuse the brain and spinal cord

IV GA's are used throughout surgery as the depth of anaesthesia can be rapidly altered by altering drug concentration

IV GA's can accumulate in fatty tissue

IV GAs with a low blood:gas coefficient produce rapid induction and recovery (NO + desflurane)

Have a high blood/gas coeffieicnt

have a low oil/gas coeffeiceint

Have a low blood/gas coeffieicnt

have a high oil/gas coeffeiceint