Biology of Cancer

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Evading growth suppressors = evade stop signals

G1 phase = vital checkpoint, antigrowth signals exert their influence to block cell proliferation Antigrowth signals in normal cells block proliferation in multiple ways: - Induction of the G0 phase (cease division) - Induction of a postmitotic state, usually involving terminal differentiation of the cell Rb and p53 control cell cycle Rb actively inhibits cell passage through the restriction point before G1 cell-cycle phase - Cancer cells with mutated Rb remove this gatekeeper and allow for ongoing cell proliferation p53 functions as a central regulator of apoptosis - arrests cell cycle in cells with DNA damage - Loss of p53 allows for cell-cycle progression despite DNA damage and cellular stresses





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