Metabolism

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Match the enzymes to their function

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Carbomoyl phosphate synthase

Hormone sensitive lipase

Adipose triglyceride lipase

CPT1

Fatty acid oxidase

Acetyl coA carboxylase

HMG CoA synthase

CPT- 2

Glycogen synthase

Protein kinase A (PKA)

Phosphorylase kinase

Glycogen phosphorylase

Glucokinase regulatory protein (GKRP)

Phosphofructokinase 1

PFK-2

AMP kinase

Alcohol dehygrogenase

Glucose 6 phosphatase

Fructose 1 6 phosphatase

Pyruvate carboxylase

Malate dehydrogenase

Phosphoenolpyruvate carboxykinase

Lactate dehydrogenase enzyme

Pyruvate dehydrogenase complex

ETC complex I

ETC complex II

ETC complex III

ETC complex IV

ATP synthase

HIF1 ( hypoxia- inducible factor 1)

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The enzyme that phosphorylates and activates glycogen phosphorylase.

Converts pyruvate to lactate in the muscle and the reverse in the liver.

Responsible for the breakdown of glycogen within cells. Activated by phosphorlyation cascade.

The enzyme that converts fructose-6-p to fructose-1,6-P2 The rate limiting step in glycolysis.

Reverses the reaction that is catalysed by Glucokinase. Converts glucose -6-p to glucose

The alpha subunit is normally degraded in norrmoxia but stabilises in hypoxia. This enzyme downregulates mitochondrial biogeesis and proliferation via the PGC-1 transcription factor and encourages autophagy of existing mitochondria. Up regulates glycolysis genes.

Prominent phosphorylation enzyme, responds to cAMP and as such is prominent in glucagons metabolic control.

This enzyme is present in the heart tissue and is activated by AMPK. It produces fructose-26- P2. Which allosterically activatess PK1

Creates ATP using the energy form the release of H+ down an electrochemical gradient from the space between the mitochondrial membranes.

Cytochrome C to O2 - does pump protons

The control step for ketone body synthesis, creates HMG CoA from acetyl coA and acetoacetyl CoA

Converts NADH to UQ- does pump protos

Converts FADH to UQ - does not pump protons

Converts the carnitine phosphate back into fatty acyl CoA once it is back in the mitochondria.

Control stage for the synthesis of glycogen.

This enzyme converts oxaloacetate to phosphoenolpyruvate in order to continue gluconeogenesis.

Unidirectional 3 stage enzyme that converts pyruvate to acetyl CoA. Active when not phosphorylated. Requires Vit B1 as a cofactor.

Coverts UQ to cytochrome C - does pump protons

Heterotrimer that can sense energy levels using its gamma subunit. Increase GLUT presence in the cell membrane in order to increase glucose uptake. This enzyme will also deactivate ACC in order to maximize the Beta oxidation in the cell.

Converts fructose-1,6- P2 to F1P. Reverses the reaction of PFK

The first enzyme involved in gluconeogensis. Converts pyruvate to oxaloacetate.

Converts triacyglycerides to diacylglycerdes.

This enzyme converts oxaloacetate to malate so that it can exit the mitochondrial membrane. This is the key enzyme in the malate shuttle.

This enzyme is vital to the carnitine shuttle that allows the movement of fatty acids across the mitochondrial membrane. Converts acylated fatty acids to carnatine phosphate and pass them over the membrane

The enzyme that controls the location of hepatic glucokinase. Releases GK i response to high sugar conc.

Control step for triglyceride breakdown. Converts TAG to glycerol and 3 FA's

This enzyme breaks down ethanol into Acetylaldehyde. This creates lots of NADH and ends up producing high levels of acetyl CoA

The enzyme that is vital for fatty acid breakdown. Converts fatty acid to acetyl CoA and reduced cofactors.

This enzyme is vital for the synthesis of fatty acids. it converts citrate derived acetyl CoA into malonyl coA

Control step for the entry of the urea cycle. Coverts ammonia and CO2


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