UoM Parasitology Lecture 15-20 (Year 2, Sem 2, 2017)

uom-parasitology-lecture-15-20-year-2-sem-2-2017

Question 1 of 1

Time Left

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Choose the incorrect reason to why most children in low income countries harbour helminth infections for most of their life.

Select the correct answer(s).

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Highlight the biological feature of a nematode infection that is incorrect.

Select the correct answer(s).

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Highlight the biological feature of a nematode infection that is incorrect.

Select the correct answer(s).

(0/0)

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Which of the clinical manifestations is more rare in helminth infection?

Select the correct answer(s).

(0/0)

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Immunoepidemiological studies are the immune factors controlling patterns of infection (Epidemiological studies). Which of the characteristics are not involved in epidemiology?

Select the correct answer(s).

(0/0)

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Laboratory models are important for learning mroe about immunity and helminth infections. Which of these isn't a real reason for these laboratory studies?

Select the correct answer(s).

(0/0)

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There are 4 defined components of infection in epidemiology of parasitic infection. Match the component with what the component is like in a low income community with infection.

Match the text (click and drag)

(0/0)

Match the text
Distribution of infection
Prevalence of infection
Intensity of infection
Predisposition to infection

Click and drag
Amount of parasite in each age. Overdispersed and highest amount of eggs in the young
Proportion of the population age infected. Highest in the young.
Activity and behaivours that determine rate of acquisition of infection. Greater in children due to geophagia, reaquisition is greater in higher worm burdens.
Maximum infection morbidity per gram of egg in stool. Higher in the young.

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Which of these characteristics of well defined laboratory models are not helpful for infection prevention research?

Select the correct answer(s).

(0/0)

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Understanding immunity to infection is required for diagnosis (immunological assays), control (identify candidate antigens and stop transmission) and understanding (vaccines). Match the diagnosis tool with its definition.

Match the text (click and drag)

(0/0)

Match the text
Peripheral compartment
Biopsy
Field study

Click and drag
Look at infected intestinal epithelia
Serum sample for parasite antibodies or peripheral blood lymphocytes (cytokine responses of th1 and th2)
Blood samples pre and post treatment or stool samples (assesses reinfection)

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What statement is true about Ig levels and Trichuris trichuria infection?

Select the correct answer(s).

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Explanation

IgE is controlled by the Th2 isotype

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There are four main types of rodent parasite studied in laboratory settings. Identify the parasite not studied in rodents.

Select the correct answer(s).

(0/0)

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Parasite vaccines are very difficult and ineffective for many reasons. Which is not a reason?

Select the correct answer(s).

(0/0)

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300

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Match the type of vaccine with its description and example.

Match the text (click and drag)

(0/0)

Match the text
Dead/Attenuated vaccine
Recombinant antigens
Live vaccine
Extract
Purified antigens
DNA vaccines

Click and drag
Irradiated larvae/parasite that dies at a certain stage. Dictyocaulus viviparus (lungworm/husk) was cured with this vaccine. Irradiated sporozoites of malaria worked in animals tested and conferred sterile immunity in humans.
Antigens are generated by cDNA expressed in an E.coli vector + screening. 3 major antigens are found against Taenia ovis oncospheres in sheep (Taenia taenaeformis model used). Echinococcus granulosus, T. saginata and T. solium homologues have been found and are on trial. Sporozoite vaccines of Hep B surface antigens (merozoite MSP-1/AMA-1), reduced prevalence by 65% in population.
DNA of a disease used to encode virus protein in cells to create environment for immunity. P. falciparum CS protein induces strong CD8 T-cytotoxic response in mice and humans.
The best immune response but extremely risky and not often used
Single antigen confering enough of a protein to form an immune response. RTS = 207-395 amino acids of circumsporozoite protein on Hep B surface antigen, with 19 NANP tetrapeptide repeats. ASO2 = oil/water adjuvant wth lipid A and saponin derivative QS21, has high CS repeats and has large th1 response that increase IFN-gamma (30% less likely)
Products or parts of the parasite are used

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Dictyocaulus viviparus is a cow lungworm causing the disease husk. Order the steps involved in its lifecycle.

Match the text (click and drag)

(0/0)

Match the Text
1
2
3
4
5
6
7

Click and drag
Eggs hatch in the host releasing L1 larvae
Start - Adult worm in the lungs
L3 is ingested by host feeding
L3 penetrates the mucosa and enters the lymph node
It moults to stage 4 and passes into the lungs, moulting to a juvenile and then growing to an adult
L1 larvae pass out of the faeces
L1 moults 2x to produce infective L3

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UoM Parasitology Lecture 15-20 (Year 2, Sem 2, 2017)

Question 1 of 1

Time Left

Choose the incorrect reason to why most children in low income countries harbour helminth infections for most of their life.

Select the correct answer(s).

(0/0)

Highlight the biological feature of a nematode infection that is incorrect.

Select the correct answer(s).

(0/0)

Highlight the biological feature of a nematode infection that is incorrect.

Select the correct answer(s).

(0/0)

Which of the clinical manifestations is more rare in helminth infection?

Select the correct answer(s).

(0/0)

Immunoepidemiological studies are the immune factors controlling patterns of infection (Epidemiological studies). Which of the characteristics are not involved in epidemiology?

Select the correct answer(s).

(0/0)

Laboratory models are important for learning mroe about immunity and helminth infections. Which of these isn't a real reason for these laboratory studies?

Select the correct answer(s).

(0/0)

There are 4 defined components of infection in epidemiology of parasitic infection. Match the component with what the component is like in a low income community with infection.

Match the text (click and drag)

(0/0)

Distribution of infection

Prevalence of infection

Intensity of infection

Predisposition to infection

Amount of parasite in each age. Overdispersed and highest amount of eggs in the young

Proportion of the population age infected. Highest in the young.

Activity and behaivours that determine rate of acquisition of infection. Greater in children due to geophagia, reaquisition is greater in higher worm burdens.

Maximum infection morbidity per gram of egg in stool. Higher in the young.

Which of these characteristics of well defined laboratory models are not helpful for infection prevention research?

Select the correct answer(s).

(0/0)

Understanding immunity to infection is required for diagnosis (immunological assays), control (identify candidate antigens and stop transmission) and understanding (vaccines). Match the diagnosis tool with its definition.

Match the text (click and drag)

(0/0)

Peripheral compartment

Biopsy

Field study

Look at infected intestinal epithelia

Serum sample for parasite antibodies or peripheral blood lymphocytes (cytokine responses of th1 and th2)

Blood samples pre and post treatment or stool samples (assesses reinfection)

What statement is true about Ig levels and Trichuris trichuria infection?

Select the correct answer(s).

(0/0)

Explanation

There are four main types of rodent parasite studied in laboratory settings. Identify the parasite not studied in rodents.

Select the correct answer(s).

(0/0)

Parasite vaccines are very difficult and ineffective for many reasons. Which is not a reason?

Select the correct answer(s).

(0/0)

Match the type of vaccine with its description and example.

Match the text (click and drag)

(0/0)

Dead/Attenuated vaccine

Recombinant antigens

Live vaccine

Extract

Purified antigens

DNA vaccines

Irradiated larvae/parasite that dies at a certain stage. Dictyocaulus viviparus (lungworm/husk) was cured with this vaccine. Irradiated sporozoites of malaria worked in animals tested and conferred sterile immunity in humans.

DNA of a disease used to encode virus protein in cells to create environment for immunity. P. falciparum CS protein induces strong CD8 T-cytotoxic response in mice and humans.

The best immune response but extremely risky and not often used

Products or parts of the parasite are used

Dictyocaulus viviparus is a cow lungworm causing the disease husk. Order the steps involved in its lifecycle.

Match the text (click and drag)

(0/0)

1

2

3

4

5

6

7

Eggs hatch in the host releasing L1 larvae

Start - Adult worm in the lungs

L3 is ingested by host feeding