Stage 4 CSIM2 - Multi-system Disease Quiz

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0 [{"id":627224,"quiz_id":"30700","answer_id":null,"answerType_id":"0","created_at":"2018-11-26 10:59:31","updated_at":"2018-11-27 09:13:16","questionName":"For patients with aCTD in pregnancy which drug can be used for severe refractory disease (does not respond to attempted forms of treatment) and in which trimester?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":1,"explanation":"The best answer here is Cyclophosphamide, 3rd trimester. Cyclophosphamide is a teratogen but since the foetus has developed this can be used in the 3rd trimester in severe disease. Azathioprine is safe through pregnancy but would have already been tried since the disease isn't responding to treatment.","question_score_id":null,"lang":"","questionAudioPath":null},{"id":627226,"quiz_id":"30700","answer_id":null,"answerType_id":"0","created_at":"2018-11-26 11:01:12","updated_at":"2018-11-27 09:13:16","questionName":"In aCTD which drug would be safe to use in the 1st trimester but is associated with B-cell depletion in neonates so is not given in the 2nd or 3rd trimesters?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":2,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":626235,"quiz_id":"30700","answer_id":null,"answerType_id":"2","created_at":"2018-11-25 19:04:08","updated_at":"2018-11-27 09:13:16","questionName":"Autoimmune diseases can be organ specific or systemic. Match these diseases with the specific organ.","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":6,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":626255,"quiz_id":"30700","answer_id":null,"answerType_id":"0","created_at":"2018-11-25 19:27:21","updated_at":"2018-11-27 09:13:16","questionName":"Which disease can present with: sarcoidosis but on the face and a pinky purple rash?\r\n","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":14,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":626240,"quiz_id":"30700","answer_id":null,"answerType_id":"3","created_at":"2018-11-25 19:13:40","updated_at":"2018-11-27 09:13:16","questionName":"Put the following theory of how SLE occurs in order...","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":9,"explanation":"1. Environmental triggers like infections\/UV light cause DNA DAMAGE\r\n2. This causes a defect in clearance of APOPTOTIC cells, whereby the nuclear material is exposed to the APCs (rather than being folded away and hidden from them)\r\n3. The antigens are presented at the thymus, and B-cells produce ANTIBODIES against the NUCLEAR CONSTITUENTS and cell membranes\r\n4. (This causes the lymph nodes to swell)\r\n5. Immune complexes form and deposit in tissues\r\n6. This support inflammation and tissue destruction via recruitment of inflammatory cells (Abs opsonise, other cells destroy)\r\n","question_score_id":null,"lang":"","questionAudioPath":null},{"id":626237,"quiz_id":"30700","answer_id":null,"answerType_id":"0","created_at":"2018-11-25 19:07:37","updated_at":"2018-11-27 09:13:16","questionName":"Which one of these is not a systemic autoimmune disease?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":7,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":627221,"quiz_id":"30700","answer_id":null,"answerType_id":"0","created_at":"2018-11-26 10:54:02","updated_at":"2018-11-27 09:13:16","questionName":"Which drugs are safe to use in pregnancy with patients who have an aCTD?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":0,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":627233,"quiz_id":"30700","answer_id":null,"answerType_id":"0","created_at":"2018-11-26 11:15:05","updated_at":"2018-11-27 09:13:16","questionName":"Which one of these is NOT an acquired endocrine cutaneous manifestation of systemic disease?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":5,"explanation":"Acanthosis nigricans is found in T2DM which is a metabolic disease.","question_score_id":null,"lang":"","questionAudioPath":null},{"id":626238,"quiz_id":"30700","answer_id":null,"answerType_id":"0","created_at":"2018-11-25 19:10:54","updated_at":"2018-11-27 09:13:16","questionName":"Which one of these is not part of the epidemiology of SLE?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":8,"explanation":"There is an increased risk with HLA DR2 and DR3. There is a second spike of cases between the ages of 50-60.","question_score_id":null,"lang":"","questionAudioPath":null},{"id":627534,"quiz_id":"30700","answer_id":null,"answerType_id":"0","created_at":"2018-11-26 11:20:58","updated_at":"2018-11-27 09:13:16","questionName":"How does acute intermittent porphyria present?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":13,"explanation":"PORPHYRIA \u2013 \u201cpurple\u201d\r\no\tThere\u2019s lots of types\r\no\tAll can present in the skin, apart from acute intermittent porphyria (abdominal pain)\r\n","question_score_id":null,"lang":"","questionAudioPath":null},{"id":626243,"quiz_id":"30700","answer_id":null,"answerType_id":"0","created_at":"2018-11-25 19:19:08","updated_at":"2018-11-27 09:13:16","questionName":"Which of the following blood tests would you perform when monitor disease activity in patient's with an autoimmune connective tissue disease?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":11,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":627229,"quiz_id":"30700","answer_id":null,"answerType_id":"0","created_at":"2018-11-26 11:07:36","updated_at":"2018-11-27 09:13:16","questionName":"You see a 69 yo female who was previously fit and well \u2013 taking part in curling. She reports tops of leg muscles stiffness and pain on walking which progressively worsens throughout the day. PMH \u2013 hypertension, cervical spondylosis. DHx \u2013 Atenolol 50mg OD, Ibuprofen 400mg PRN. SHx \u2013 lifelong smoker, cut down for 20p\/d to 5\/d. 18-month history of fingers becoming numb and white on cold exposure, which was worse in the winter. Subsequently, her fingers became dusky purple, then red and painful as they gradually returned to normal. Weight = 45kg. What 4 risk factors does this patient have for her condition?\r\n","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":3,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":626241,"quiz_id":"30700","answer_id":null,"answerType_id":"0","created_at":"2018-11-25 19:15:56","updated_at":"2018-11-27 09:13:16","questionName":"Which investigations do you need to perform every time when seeing a patient with SLE?","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":10,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":626251,"quiz_id":"30700","answer_id":null,"answerType_id":"0","created_at":"2018-11-25 19:26:19","updated_at":"2018-11-27 09:13:16","questionName":"Which disease can present with: TB skin infection (the most common one); Often on face, painful; Small, reddish-brown, defined lesions; Gelatinous nodules (\u201capple jelly nodules\u201d)?\r\n","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":12,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null},{"id":627231,"quiz_id":"30700","answer_id":null,"answerType_id":"2","created_at":"2018-11-26 11:11:00","updated_at":"2018-11-27 09:13:16","questionName":"Match the sign\/symptom to the correct condition...","questionTimeSeconds":"0","questionTimeMinutes":"2","questionImagePath":null,"position":4,"explanation":"","question_score_id":null,"lang":"","questionAudioPath":null}]
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For patients with aCTD in pregnancy which drug can be used for severe refractory disease (does not respond to attempted forms of treatment) and in which trimester?

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